L-THREO-DIHYDROSPHINGOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.

Allgemeine Beschreibung

A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and ³H-phorbol dibutyrate binding of purified rat brain PKC (IC₅₀ = 37.5 μM and 31 μM, respectively). Inhibits human PKC_α, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC₅₀ = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.

Biochem/physiol Actions

Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.

L-THREO-DIHYDROSPHINGOSINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

L-THREO-DIHYDROSPHINGOSINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30239	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49978	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4674	55
Yichang Zhongyitai Trading Co., Ltd.	0717-6449896 13886658719	root@zhongyitai.com	China	1977	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Alfa Chemistry	1-516-6625404	support@alfa-chemistry.com	United States	9171	60
Codow Chemical Co.,Ltd.	18620099427	amy@howeipharm.com	China	17687	55

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• SAFINGOL
• L-THREO-SPHINGANINE, C18 CHAIN
• L-THREO-DIHYDROSPHINGOSINE
• L-threo-dihydrospingosine
• L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL
• L-threo-dihydrosphingosine (d18:0)
• 1,3-Octadecanediol, 2-amino-, (2S,3S)-
• Safingol - CAS 15639-50-6 - Calbiochem
• L-threo-Dihydrosphingosine (Safingol)
• 15639-50-6
• Biochemicals and Reagents
• BioChemical
• Lipids
• Sphingolipids
• Sphinganines
• Sphingoid bases