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Cargutocin

Cargutocin Struktur
33605-67-3
CAS-Nr.
33605-67-3
Englisch Name:
Cargutocin
Synonyma:
Y-5350;Statogin;Cargutocin;Cargutocin USP/EP/BP;1-Butyryl-7-glycyl-1,6-dicarbaoxytocin;Butyryl(1)-L-Tyr-L-Ile-L-Gln-L-Asn-L-Abu(1)-Gly-L-Leu-Gly-NH2;Glycinamide, L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-(2S)-7-carboxyheptanoylglycyl-L-leucyl-, (5→1)-lactam;(2S,5S,8S,11S)-5-[(2S)-butan-2-yl]-8-(2-carbamoylethyl)-11-(carbamoylmethyl)-N-[[(1S)-1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoylmethyl]-2-[(4-hydroxyphenyl)methyl]-3,6,9,12,20-pentaoxo-1,4,7,10,13-pentazacycloicosane-14-carboxamide
CBNumber:
CB11178220
Summenformel:
C42H65N11O12
Molgewicht:
916.041
MOL-Datei:
33605-67-3.mol

Cargutocin Eigenschaften

alpha 
D25 -44.0° (c = 0.55 in water)
Siedepunkt:
801.01°C (rough estimate)
Dichte
1.1903 (rough estimate)
Brechungsindex
1.6500 (estimate)
CAS Datenbank
33605-67-3

Sicherheit

Cargutocin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Statocin,Yoshitomi,Japan,1982

Manufacturing Process

To a suspension of Z-Tyr(Bz)-Ile-Gln-Asn-Asu(OTCP)-Gly-Leu-Gly-NH2 (1,310 mg) in DMF (350 ml) is added a suitable amount of palladium black. Hydrogen gas is introduced with stirring at room temperature (25°C) for about 40 hours. After stirring the mixture at 30°-35°C for several hours, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. A large amount of ether is added to the residue, and the white coagulum is collected by filtration, washed with ether and dried. This is dissolved in water (30 ml), and the solution is filtered. The filtrate is passed through a column (3 x 11.5 cm) of Amerlite IR-45 (OH-form). The fractions which show a UV-absorption maximum at 280 nm are combined and passed through a column (3 x 125 cm) of CM-Sephadex C-25 to remove the noncyclic compound and obtain neutral parts. The detection of the objective compound is made by UV_x0002_absorption at 280 nm. The aqueous solution of the neutral parts is concentrated below 35°C, under reduced pressure, and the concentrate is lyophilized to give 504 mg of the crude title compound in the form of 5 hydrate.

Therapeutic Function

Oxytocic

Cargutocin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cargutocin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919
Eric@peptidego.com China 6968 58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD 0571-87213919 17306812703
3007955328@qq.com China 6659 58

33605-67-3()Verwandte Suche:


  • Cargutocin
  • 1-Butyryl-7-glycyl-1,6-dicarbaoxytocin
  • Butyryl(1)-L-Tyr-L-Ile-L-Gln-L-Asn-L-Abu(1)-Gly-L-Leu-Gly-NH2
  • Statogin
  • Y-5350
  • (2S,5S,8S,11S)-5-[(2S)-butan-2-yl]-8-(2-carbamoylethyl)-11-(carbamoylmethyl)-N-[[(1S)-1-(carbamoylmethylcarbamoyl)-3-methyl-butyl]carbamoylmethyl]-2-[(4-hydroxyphenyl)methyl]-3,6,9,12,20-pentaoxo-1,4,7,10,13-pentazacycloicosane-14-carboxamide
  • Glycinamide, L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-(2S)-7-carboxyheptanoylglycyl-L-leucyl-, (5→1)-lactam
  • Cargutocin USP/EP/BP
  • 33605-67-3
  • C42H65N11O12
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