DEMETHOXYCURCUMIN
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- CAS-Nr.
- 22608-11-3
- Englisch Name:
- DEMETHOXYCURCUMIN
- Synonyma:
- emethoxycurcumin;Demethoxycurcumin;Curcumin Desmethoxy;Demethoxycurcumin-RM;DEMETHOXYCURCUMIN(SH);MonodeMethoxycurcuMin;Z/E-Desmethoxycurcumin;Demethoxycurcumin (AS);(2E)-DeMethoxy CurcuMin;(E,E)-demethoxycurcumin
- CBNumber:
- CB0960423
- Summenformel:
- C20H18O5
- Molgewicht:
- 338.35
- MOL-Datei:
- 22608-11-3.mol
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DEMETHOXYCURCUMIN Eigenschaften
- Schmelzpunkt:
- 166～170℃
- Siedepunkt:
- 571.4±50.0 °C(Predicted)
- Dichte
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- pka
- 8.31±0.46(Predicted)
- Aggregatzustand
- powder
- Farbe
- orange
- LogP
- 3.113 (est)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50 |
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| S-S?tze: |
61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
2 |
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| HS Code |
29145090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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DEMETHOXYCURCUMIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS.
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.
DEMETHOXYCURCUMIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DEMETHOXYCURCUMIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 184)Lieferanten
22608-11-3()Verwandte Suche:
- Feruloyl-P-hydroxycinnnamoylmethane
- MonodeMethoxycurcuMin
- (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-heptadiene-3,5-d
- (E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
- 1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione
- DeMethoxyCurcuMin(DesMethoxycurcuMin)
- p-HydroxycinnaMoylferuloylMethane
- Demethoxycurcumin
- 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
- 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-
- DEMETHOXYCURCUMIN(SH)
- (2E)-DeMethoxy CurcuMin
- Demethoxycurcumin, 98%, from Curcuma longa L.
- (1E,6E)-Demethoxycurcumin
- Z/E-Desmethoxycurcumin
- 1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-
- Curcumin Desmethoxy
- DEMETHOXYCURCUMIN USP/EP/BP
- (E,E)-demethoxycurcumin
- Demethoxycurcumin (Mixture of Isomers)
- emethoxycurcumin
- Demethoxycurcumin (AS)
- Curcumin II|||Desmethoxycurcumin|||Monodemethoxycurcumin
- Demethoxycurcumin-RM
- 22608-11-3
- 33173-16-3
- Aromatics
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
