天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

BEC

BEC Struktur
63107-40-4
CAS-Nr.
63107-40-4
Englisch Name:
BEC
Synonyma:
BEC;S-(2-BORONOETHYL)-L-CYSTEINE;L-Cysteine, S-(2-boronoethyl)-;Arginase II(BEC hydrochloride);(2S)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid
CBNumber:
CB0700230
Summenformel:
C5H12BNO4S
Molgewicht:
193.03
MOL-Datei:
63107-40-4.mol

BEC Eigenschaften

Siedepunkt:
451.6±55.0 °C(Predicted)
Dichte
1.372±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
PBS (pH 7.2): 5 mg/ml
Aggregatzustand
powder
pka
2.10±0.10(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

BEC Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 μM. It is also a potent inhibitor of human arginase II with Ki values of 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.

Biochem/physiol Actions

BEC (S-(2-boronoethyl)-l-cysteine) is a potent and specific arginase inhibitor that restores flow-induced responses in arterioles from diabetic rats.

Enzyminhibitor

This boronic acid-containing arginine analogue (FW = 190.00 g/mol; CAS 63107-40-4; Abbreviation: BEC) is a slow, tight-binding competitive inhibitor of arginase (Reaction: L-Arginine + H2O ? Urea + L-Ornithine), the binuclear manganese metalloenzyme catalyzing the last step in the Urea Cycle. Upon binding, the boronic acid moiety undergoes nucleophilic attack by the enzyme’s metal-bridging hydroxide ion, yielding a tetrahedral boronate anion that bridges the binuclear manganese cluster and mimics the tetrahedral intermediate (or a flanking transition state configuration) in arginase catalysis. BEC is also a potent inhibitor of human arginase II with Ki values of 0.31 μM and 30 nM at pH 7.5 and 9.5, respectively. Inhibition of arginase by BEC increases the circulating concentration of arginine, thereby increasing nitric oxide synthesis and significantly enhancing NO-dependent smooth muscle relaxation in human penile corpus cavernosum. Arginase is thus a potential druggable target for the treatment of erectile dysfunction.

BEC Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BEC Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 49)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203
info@chemextension.com China 42056 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
BOC Sciences --
info@bocsci.com USA 0 65
Shanghai Anhua Biotechnology Co., Ltd. 021-61263375 18168859245
China 5958 58
Wuxi maimo topp biotechnology co., LTD 13771048682
alice@mimotopes.cn China 5829 58
Jiangsu Hongmin Pharmaceutical Co., Ltd. 18221292452
fannieliu@glschina.com China 6798 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11218 58

63107-40-4()Verwandte Suche:


  • BEC
  • S-(2-BORONOETHYL)-L-CYSTEINE
  • L-Cysteine, S-(2-boronoethyl)-
  • (2S)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid
  • Arginase II(BEC hydrochloride)
  • 63107-40-4
Copyright 2019 ? ChemicalBook. All rights reserved