Y-27632 DIHYDROCHLORIDE
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- CAS-Nr.
- 146986-50-7
- Englisch Name:
- Y-27632 DIHYDROCHLORIDE
- Synonyma:
- Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 (2HCl),98%;Y-27632, free base;Y-27632 dihydrochlor
- CBNumber:
- CB0699488
- Summenformel:
- C14H21N3O
- Molgewicht:
- 247.34
- MOL-Datei:
- 146986-50-7.mol
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Y-27632 DIHYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- >260°C (dec.)
- Siedepunkt:
- 462.6±15.0 °C(Predicted)
- Dichte
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- H2O: 14 mg/mL
- Aggregatzustand
- solid
- pka
- 13.53±0.40(Predicted)
- Farbe
- white
- Stabilit?t:
- Hygroscopic
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
20/21/22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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Y-27632 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Definition
ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti
ity against Rho-associated protein kinase (ROCK) enzyme.
Biologische Aktivit?t
Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.
Y-27632 DIHYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Y-27632 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 166)Lieferanten
146986-50-7()Verwandte Suche:
- (R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL
- (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
- (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O
- Y-27632 DIHYDROCHLORIDE
- TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE
- 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride
- (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride
- CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans-
- Y-27632/Y27632
- Y-27632, Free Base, >99%
- (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide
- Y-27632 (2HCl),98%
- Y-27632, free base
- 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide
- 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
- (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride
- 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide
- CS-20
- 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide
- (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide
- (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide
- Y-27632 dihydrochlor
- ROCK INHIBITOR
- Y-27632
- Y-276322HCl
- (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
- Rock inhibitor y-27632
- trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
- trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide , Y-27632
- 146986-50-7
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Kinase/Phosphatase Biology
- Rho Kinase (ROCK)
- Serine/Threonine Kinase Inhibitors
- Inhibitors
- Protein Kinase
- Signalling
- Inhibitor
- APIs
- SiChem
