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CYP2A6

CYP2A6 Struktur
CAS-Nr.
Englisch Name:
CYP2A6
Synonyma:
CYP2A6
CBNumber:
CB05298879
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

CYP2A6 Eigenschaften

Sicherheit

CYP2A6 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The CYP2A6 is the only member of this subfamily that is expressed primarily in the liver and also may be expressed in lung and nasal epithelium. It has a low level of hepatic expression and represents approximately 4% of the total hepatic CYP450 isoforms. It catalyzes the 7-hydroxylation of coumarin (coumarin 7-hydroxylase), hydroxylation of aflatoxin B1, nicotine (C-oxidation to cotinine), naproxen, tacrine, clozapine, mexiletine, and cyclobenzaprine as well as the bioactivation of nitrosamines and procarcinogens. The CYP2A6 exhibits polymorphism with an incidence of 2% in the Caucasian population. This population is characterized as poor metabolizers. Smokers with a defective CYP2A6 gene smoke fewer cigarettes, implicating a genetic factor in nicotine dependence.

CYP2A6 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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