SU 6656 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The Src family of proto-
oncogenic kinases include nine mammalian non-
receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC
50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.
Verwenden
SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.
Allgemeine Beschreibung
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC
50 = 280 nM) as well as closely related kinases Fyn (IC
50 = 170 nM), Yes (IC
50 = 20 nM) and Lyn (IC
50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC
50 = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC
50 ≥10 μM) and IGF-1 receptor kinase (IC
50 ≥20 μM).
SU 6656 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
