N-Benzyloxycarbonyl-L-prolin
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- CAS-Nr.
- 1148-11-4
- Bezeichnung:
- N-Benzyloxycarbonyl-L-prolin
- Englisch Name:
- N-Benzyloxycarbonyl-L-proline
- Synonyma:
- Z-Pro;Z-PRO-OH;CBZ-PRO-OH;Z-L-PRO-OH;N-CBZ-L-PROLINE;CBZ-L-Pro-OH;CARBOBENZYLOXY-L-PROLINE;N-CARBOBENZYLOXY-L-PROLINE;(S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid;Z-PROLINE
- CBNumber:
- CB0370381
- Summenformel:
- C13H15NO4
- Molgewicht:
- 249.26
- MOL-Datei:
- 1148-11-4.mol
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N-Benzyloxycarbonyl-L-prolin Eigenschaften
- Schmelzpunkt:
- 75-77 °C
- alpha
- -60 º (c=2,AcOH)
- Siedepunkt:
- 392.36°C (rough estimate)
- Dichte
- 1.1952 (rough estimate)
- Brechungsindex
- -40 ° (C=2, EtOH)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Solubility in methanol, almost transparency.
- Aggregatzustand
- Crystalline Powder or Crystals
- pka
- 3.99±0.20(Predicted)
- Farbe
- White to off-white
- Optische Aktivit?t
- [α]20/D 42°, c = 2 in ethanol
- BRN
- 88579
- InChIKey
- JXGVXCZADZNAMJ-NSHDSACASA-N
- CAS Datenbank
- 1148-11-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS05.jpg" width="20" height="20" /> |
P280, P305+P351+P338, P310 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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N-Benzyloxycarbonyl-L-prolin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.
synthetische
Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.
N-Benzyloxycarbonyl-L-prolin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-Benzyloxycarbonyl-L-prolin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 519)Lieferanten
1148-11-4(N-Benzyloxycarbonyl-L-prolin)Verwandte Suche:
- n-benzyloxycarbonylproline
- N-Benzyloxycarbonyl-L-proline~Z-Pro-OH
- N-cbz-L-proline crystalline
- N-CBZ-L-Proline N-Carbobenzyloxy-L-proline
- N-Cbz-L-Pro-OH
- carbobenzoxyproline
- N-Benzyloxycarbonyl-L-proline, 98+%
- L-Cbz-ProlineN
- Z-L-PROLINE extrapure
- N-Cbz-L-proline, 98+%
- 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-
- N-[(Phenylmethoxy)carbonyl]-L-proline
- N-Benzyloxycarbonyl-(S)-proline
- (2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester
- (2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester
- N-Carbobenzyloxy-L-proline,99%
- (2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected
- L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid
- N-Carbobenzyloxy-L-proline, 99% 10GR
- N-Cbz-L-proline
Z-Pro-OH
- (2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid
- (S)-N-Benzyloxycarbonyl-L-proline
- 1-benzylester,l-2-pyrrolidinedicarboxylicacid
- benzyloxycarbonylproline
- carbobenzoxy-l-proline
- carbobenzoxy-s-proline
- Z-Pro-OH 99%
- l-1,2-pyrrolidinedicarboxylicacid1-benzylester
- 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-
- 1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid
- (S)-Z-pyrrolidine-2-carboxylic acid
- Z-L-proline≥ 99% (HPLC)
- 1-[(BENZYLOXY)CARBONYL]-L-PROLINE
- 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)-
- (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID
- CBZ-L-PROLINE
- L-CBZ-PROLINE
- BENZYLOXYCARBONYL-L-PROLINE
- (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID
- N-ALPHA-BENZYLOXYCARBONYL-L-PROLINE
- N-BENZYLOXYCARBONYL-L-PROLINE
- N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID
- N-ALPHA-CARBOBENZOXY-L-PROLINE
- N-ALPHA-CBZ-L-PROLINE
- N-CBZ-L-PROLINE-OH
- N-CARBOBENZOXY-L-PROLINE
- Z-PROLINE
- Z-PYRD(2)-OH
- 1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid
- N-Carbobenzoxy-L-proline >
- (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylicaci
- N-Benzyloxycarbonyl-L-proline USP/EP/BP
- N-BENZYLOXYCARBONY-L-PROLIN
- TIANFU CHEM N-Benzyloxycarbonyl-L-proline
- Fmoc-Thr(Ac?AcNH-α-Gal)-OH
- ZINC77292789
- CBZ-L-Pro-OH
- (S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid
