Boc-His(Trt)-OH
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- CAS-Nr.
- 32926-43-5
- Englisch Name:
- Boc-His(Trt)-OH
- Synonyma:
- BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
- CBNumber:
- CB0342634
- Summenformel:
- C30H31N3O4
- Molgewicht:
- 497.58
- MOL-Datei:
- 32926-43-5.mol
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Boc-His(Trt)-OH Eigenschaften
- Schmelzpunkt:
- ~130 °C (dec.)
- alpha
- 12.5 º (C=1% IN MEOH)
- Siedepunkt:
- 667.5±55.0 °C(Predicted)
- Dichte
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Sparingly)
- Aggregatzustand
- Solid
- pka
- 3.17±0.10(Predicted)
- Farbe
- White to Off-White
- Optische Aktivit?t
- [α]20/D +12.5±1.0°, c = 1% in methanol
- BRN
- 732035
- InChIKey
- OYXZPXVCRAAKCM-SANMLTNESA-N
- SMILES
- C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
- CAS Datenbank
- 32926-43-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
29224999 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Boc-His(Trt)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to off white powder
Verwenden
Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.
Verwenden
Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.
Application
N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.
synthetische
The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et
2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.
reaction suitability
Reaction type: Boc solid-phase peptide synthesis
Boc-His(Trt)-OH Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Boc-His(Trt)-OH Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 247)Lieferanten
32926-43-5()Verwandte Suche:
- (S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
- N-Boc-His(Trt)-OH
- (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95%
- Boc-His(Trt)-OH >=98.0% (TLC)
- Boc-His(Trt)-OH, >=98%
- (S)-L-Boc-his(trt)-oh
- BOC-N-IM-TRITYL-L-HISTIDINE
- N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE
- N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE
- N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE
- N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE
- N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE
- L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-
- Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)
- N-Boc-N'-trityl-L-histidine
- (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
- Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine
- (Tert-Butoxy)Carbonyl His(Trt)-OH
- 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID
- N-Boc-N'-trityl-L-histidine USP/EP/BP
- Nα-Boc-Nim-trityl-L-histidine
- N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine
- (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid
- His(Trt)-OH
- BOC-L-HIS(TRT)-OH
- BOC-HIS(TRT)-OH
- Boc-His(trt)
- Boc-L-His(Trt)
- Nα-Boc-N(im)-trityl-L-histidine
- N-Boc N '- Triphenylmethyl L-histidine
- Na-(tert-butoxycarbonyl)-N-trityl-L-histidine
- N-Boc-N'-trityl-L-histidine
- N-Boc-N'-triphenylmethyl-L-histidine
- Impurity HA-1
- 32926-43-5
- C30H31N3O4
- Amino Acid Derivatives
- Histidine
- Peptide Synthesis
- Specialty Synthesis
- Boc-Amino Acids and Derivative
- Boc-Amino acid series
