Anti-calcium binding tyrosine-(Y)-phosphorylation regulated Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
SPAST (spastin) is an ATPase belonging to the AAA (ATPases associated with various cellular activities) family. It is located to chromosome 2p21-p22. It exists mainly in two isoforms, a 68kDa full-length isoform and a 60kDa short form.
Biochem/physiol Actions
SPAST (spastin) is associated with several cellular processes, such as cell cycle, vesicular transport, mitochondrial function, peroxisome biogenesis and proteolysis. It controls microtubule dynamics in neuronal cells. It binds to microtubules in an ATP-dependent manner to rearrange microtubule distribution and morphology. Mutation in SPAST causes a neurodegenerative disease, hereditary spastic paraplegias (HSPs). In addition, it also controls membrane trafficking.
Anti-calcium binding tyrosine-(Y)-phosphorylation regulated Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
