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2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Struktur
1395048-49-3
CAS-Nr.
1395048-49-3
Englisch Name:
2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
Synonyma:
M-110;CS-2124;M 110,M110;M-110 >=98% (HPLC);2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide;4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
CBNumber:
CB02750705
Summenformel:
C22H28ClN5O3
Molgewicht:
445.94
MOL-Datei:
1395048-49-3.mol

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Eigenschaften

Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble25mg/mL, clear
pka
7.46±0.40(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

M-110 is a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3. M-110 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. M-110 inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 30)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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Haoyuan Chemexpress Co., Ltd. 021-58950125
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Sigma-Aldrich 021-61415566 800-8193336
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Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195
505721671@qq.com China 3866 58
Musechem +1-800-259-7612
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Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
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DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
Cckinase, Inc. +1 (732)236-3202
sales@cckinase.com United States 2738 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
  • 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
  • M-110
  • CS-2124
  • 4-Pyridinecarboxylic acid, 2-[[3-(4-morpholinyl)propyl]amino]-, 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide
  • M-110 >=98% (HPLC)
  • M 110,M110
  • 1395048-49-3
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