4-AMino-5-Methylpyridin-2-ol
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- CAS-Nr.
- 95306-64-2
- Englisch Name:
- 4-AMino-5-Methylpyridin-2-ol
- Synonyma:
- 4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-Amino-2-hydroxy-5-methylpyridine;Degarelix Impurity 4;Finerenone Impurity A;Finerenone Impurity 28;Felodipine Impurity 14;Finerenone intermediate;4-amino-5-methylpyridone;4-AMino-5-Methylpyridin-2-ol
- CBNumber:
- CB02507291
- Summenformel:
- C6H8N2O
- Molgewicht:
- 124.14
- MOL-Datei:
- 95306-64-2.mol
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4-AMino-5-Methylpyridin-2-ol Eigenschaften
- Siedepunkt:
- 291.0±33.0℃ (760 Torr)
- Dichte
- 1.137±0.06 g/cm3 (20 ºC 760 Torr)
- Dampfdruck
- 0-0Pa at 20-50℃
- Flammpunkt:
- 129.8±25.4℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 11.90±0.10(Predicted)
- InChI
- InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
- InChIKey
- SSQZBQXJYGNUSC-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C)C(N)=C1
- LogP
- -0.51 at 20℃ and pH6.3
- CAS Datenbank
- 95306-64-2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-AMino-5-Methylpyridin-2-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
4-AMino-5-Methylpyridin-2-ol belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules. For example, the compound can prepare selective mineralocorticoid receptor (MR) antagonist finerenone, which is used to lower the risk of severe kidney and heart problems.
Synthese
2-Chloro-4-amino-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.
4-AMino-5-Methylpyridin-2-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-AMino-5-Methylpyridin-2-ol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 282)Lieferanten
- 4-AMino-5-Methyl-2-(1H)-pyridinone
- 4-AMino-5-Methylpyridin-2-ol
- 4-amino-5-methylpyridine-2(1H)-one
- 2(1H)-Pyridinone, 4-amino-5-methyl-
- 4-Amino-2-hydroxy-5-methylpyridine
- 4-AMino-5-Methylpyridin-2(1H)-one
- 4-amino-5-methyl-1H-pyridin-2-one
- 4-amino-5-methylpyridone
- 4-amino-5-methyl-1,2-dihydropyridin-2-one
- Finerenone Impurity 28
- 4-Amino-5-methyl-2-hydroxypyridine
- 4-amino-5-methylpyridine-2(1H)-on
- 4-Amino-5-methyl-2(1H)-pyridinone (4-Amino-5-methyl-2-pyridinol)
- 4-Amino-5-methylpyridine-2-ol
- Finerenone intermediate
- 4-AMino-5-Methylpyridin-2Chemicalbook(1H)-one
- Finerenone Impurity A
- Degarelix Impurity 4
- Felodipine Impurity 14
- 95306-64-2
- Intermediate
- 95306-64-2
