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Ramipril

Ramipril Struktur
87333-19-5
CAS-Nr.
87333-19-5
Englisch Name:
Ramipril
Synonyma:
ALTACE;RaMipril API;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid;DELIX;vesdil;Trimce;RAMACE;Triatec;UNIPRIL
CBNumber:
CB0249104
Summenformel:
C23H32N2O5
Molgewicht:
416.51
MOL-Datei:
87333-19-5.mol

Ramipril Eigenschaften

Schmelzpunkt:
106-108°C
Siedepunkt:
616.2±55.0 °C(Predicted)
alpha 
D24 +33.2° (c = 1 in 0.1N ethanolic HCl)
Dichte
1.200±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: ~18mg/mL
pka
pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)
Aggregatzustand
powder
Farbe
white
BCS Class
1
CAS Datenbank
87333-19-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/38
S-S?tze: 26-37/39
WGK Germany  2
RTECS-Nr. GY5879600
HS Code  2933995300
Giftige Stoffe Daten 87333-19-5(Hazardous Substances Data)
Toxizit?t LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)

Ramipril Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

Chemische Eigenschaften

White Solid

Verwenden

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

Definition

ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

Allgemeine Beschreibung

Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.

Ramipril Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ramipril Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 434)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 1001 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58

87333-19-5()Verwandte Suche:


  • Ramioril
  • (2S,3AS,6AS)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)-OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • Triatec
  • Trimce
  • vesdil
  • (1S,5S,7S)-8-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-8-azabicyclo[3.3.0]octane-7-carboxylic acid
  • Cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl), (2S-(1(R*(R*)),2-alpha,3a-beta,6a-beta))
  • 4-[2-(1-Ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-4-azabicyclo[3.3.0]octane-3-carboxylic acid
  • (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid
  • Ramipril (125 mg)
  • Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • [2S-[1[R^<*>^ (R^<*>^)],2α,3αβ,6αβ]]-1-[2-[[1- (Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahy-drocyclopenta[b]pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • RaMipril(Altace)
  • (2S,3aS,6aS)-
  • Ranipril
  • UNIPRIL
  • TRITACE
  • PRAMACE
  • RAMIPRIL
  • RAMACE
  • cyclopenta(b)pyrrole-2-carboxylicacid,octahydro-1-(2-((1-(ethoxycarbonyl)-3-p
  • [2S,3AS,6AS]-1-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • (2S,3AS,6AS)-1-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-OCTAHYDRO-CYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
  • (2s,3as,6as)-1((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester
  • RAMIPRIL, IMPURITY B(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-[(METHYLETHOXY)CARBONYL]-3-PHENYLPROPYL]AMINO] PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID(RAMIPRIL ISOPROPYL ESTER) EP STANDARD
  • RAMIPRIL, USP STANDARD
  • RAMIPRIL, EP STANDARD
  • RAMIPRIL, RELATED COMPOUND A5-[[2-(AMINOETHYL)THIO]METHYL]-N,N-DIMETHYL-2-FURANMETHANINE HEMIFUMARATE SALT USP STANDARD
  • RAMIPRIL, IMPURITY DETHYL(2S)-2-[(3S,5AS,8AS,9AS)-3-METHYL-1,4-DIOXODECAHYDRO-1H-CYCLOPENTA[E]PYRROLO[1,2A]PYRAZIN-2-YL]-4-PHENYLBUTANOATE EP STANDARD
  • RAMIPRIL, IMPURITY C(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(ETHOXYCARBONYL)-3-CYCLOHEXYLPROPYL]AMINO]PROPANOYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (HEXAHYDRORAMIPRIL) EP STANDARD
  • RAMIPRIL, IMPURITY A(2S,3AS,6AS)-1-[(S)-2-[[(S)-1-(METHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]PROPANOLY]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID (RAMIPRIL METHYLESTER) EP STANDARD
  • CARDACE
  • HOE-498
  • DELIX
  • Raimipril
  • RamiprilC23H32N205
  • HOE-498, Altace, Cardace, Delix, Pramace, Ramace, Unipril
  • Cyclopentabpyrrole-2-carboxylic acid, 1-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyloctahydro-, (2S,3aS,6aS)-
  • (2s,3as,6as)-1-[(s)-2-[[(s)-1-(ethoxycarbonyl)-3phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phoeramipril
  • (2S,3aS,6aS)-1-((S)-2-((S)-1-ethoxy-1-oxo-4-
  • CAS 87333-19-5 Ramipril Powder
  • 2S,3aS,6aS)-1((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid 1-ethyl ester
  • Ramipril CRS
  • Calcipotriol impurity MC-1080
  • Carasel
  • Ramipril USP/EP/BP
  • Ramipril (1.0 mg/mL in Methanol)
  • Ramipri
  • Ramipril (HOE-498)
  • RamiprilQ: What is Ramipril Q: What is the CAS Number of Ramipril Q: What is the storage condition of Ramipril Q: What are the applications of Ramipril
  • Ramipril (1598303)
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • RaMipril API
  • (2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl
  • ALTACE
  • 2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid
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