A77 1726
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- CAS-Nr.
- 163451-81-8
- Englisch Name:
- A77 1726
- Synonyma:
- Flucyamide;A77 1726 (Teriflunomide);2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-;A 1726;HMR 1726;A77 1726;Teriflunomide(b);Teriflunomide (cGMP);Leflunomide Impurity B;LeflunoMide EP IMpurity B
- CBNumber:
- CB02486749
- Summenformel:
- C12H9F3N2O2
- Molgewicht:
- 270.21
- MOL-Datei:
- 163451-81-8.mol
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A77 1726 Eigenschaften
- Schmelzpunkt:
- 229-232°C
- Siedepunkt:
- 410.8±45.0 °C(Predicted)
- Dichte
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 5.20±0.50(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- maximale Wellenl?nge (λmax)
- 203nm(MeOH)(lit.)
- Merck
- 14,9165
- Stabilit?t:
- Hygroscopic
- InChIKey
- UTNUDOFZCWSZMS-YFHOEESVSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| HS Code |
2926.90.4801 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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A77 1726 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In September 2012, the US FDA approved teriflunomide (also referred
to as HMR-1726) as a therapy for patients with relapsing forms of multiple
sclerosis (MS). Teriflunomide is the second approved oral treatment option
for MS, after Gilenya? which was approved in 2010. Teriflunomide, which is the active metabolite of leflunomide (a marketed
drug for the treatment of rheumatoid and psoriatic arthritis), is a non?competitive and selective inhibitor of dihydroorotate dehydrogenase
(DHODH), the rate-limiting enzyme in the de novo synthesis of pyrimidines.
Although the net effect of inhibition of DHODH by teriflunomide and its
therapeutic effect in MS are not clear, it is hypothesized that by inhibiting de novo pyrimidine synthesis, the effector functions of activated lymphocytes
are suppressed, thus dampening the effect of an overactive immune system.
Chemische Eigenschaften
White Solid
Verwenden
The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.
Definition
ChEBI: An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid
arthritis.
Allgemeine Beschreibung
Teriflunomide, marketed under the trade name Aubagio, is the active metabolite of leflunomide, an immunosuppressive disease-modifying antirheumatic drug, used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. An analytical reference standard for use in LC/MS or GC/MS applications including clinical and diagnostic testing such as therapeutic drug monitoring assays.
A77 1726 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
A77 1726 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 236)Lieferanten
163451-81-8()Verwandte Suche:
- A 1726
- HMR 1726
- (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
- LeflunoMide EP IMpurity B
- Leflunomide Impurity 2(Leflunomide EP Impurity B)
- A-771726;A 771726;A771726
- A-771726;A 77-1726;A771726;HMR-1726
- (2Z)-2-Cyano-3-hydroxy-N-[4-(triflu
- Teriflunomide(b)
- Leflunomide EP Impurity B (Teriflunomide)
- Leflunomide Impurity B
- Leflunomide EP Impurity B/ Leflunomide Related Compound B
- Teriflunomide (cGMP)
- Leflunomide impurities1341
- TeriflunomideQ: What is
Teriflunomide Q: What is the CAS Number of
Teriflunomide Q: What is the storage condition of
Teriflunomide Q: What are the applications of
Teriflunomide
- A77 1726 (Teriflunomide)
- Flucyamide
- 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
- LeflunomideEPImpurityB-d4
- A77 1726
- Leflunomide EP Impurity B
Leflunomide USP RC B
- 163451-81-8
- 204395-49-4
- Metabolites & Impurities
- Tyrosine Kinase Inhibitors
