3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
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- CAS-Nr.
- 202821-81-6
- Englisch Name:
- 3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
- Synonyma:
- BMS-A;BMS 191011;-1,3,4-oxadiazol-2(3H);-5-(4-(trifluoromethyl);-5-(4-(trifluoromethyl);BMS-191011 >=98% (HPLC);3-(5-Chloro-2-hydroxybenzyl);3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoroMethyl)phenyl)-1,3,4;3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H);3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
- CBNumber:
- CB02450344
- Summenformel:
- C16H10ClF3N2O3
- Molgewicht:
- 370.71
- MOL-Datei:
- 202821-81-6.mol
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3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Eigenschaften
- Siedepunkt:
- 444.0±55.0 °C(Predicted)
- Dichte
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- L?slichkeit
- DMSO: soluble20mg/mL, clear (warmed)
- pka
- 9.27±0.43(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BMS 191011 is an activator of large-conductance calcium-activated potassium (K
Ca1.1/BK) channels that increases maximum potassium current to 126% of control in
X. laevis oocytes expressing human K
Ca1.1 channels when used at a concentration of 1 μM.
In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the K
Ca1.1 channel blocker iberiotoxin .
Biologische Aktivit?t
Potent Maxi-K channel opener (large-conductance Ca 2+ -activated potassium channel, K Ca 1.1, BK Ca ). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 86)Lieferanten
- 3-[(5-CHLORO-2-HYDROXYPHENYL)METHYL]-5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2(3H)-ONE
- BMS 191011
- 3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one
- 3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoroMethyl)phenyl)-1,3,4
- -5-(4-(trifluoromethyl)
- -1,3,4-oxadiazol-2(3H)
- BMS-191011 >=98% (HPLC)
- 1,3,4-Oxadiazol-2(3H)-one, 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-
- BMS-A
- -5-(4-(trifluoromethyl)
- 3-(5-Chloro-2-hydroxybenzyl)
- Potassium Channel,rodent models of stroke,Panc-1,neuroprotective activity,inhibit,IGR39,BMS-191011,Inhibitor,BMS 191011,KcsA,BMS191011
- 3-(5-chloro-2-hydroxybenzyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)
- 202821-81-6
- C16H10ClF3N2O3
- C16H10ClF3N3O3
