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4-(Hydroxyamino)-4-oxobutanoic acid

4-(Hydroxyamino)-4-oxobutanoic acid Struktur
4743-99-1
CAS-Nr.
4743-99-1
Englisch Name:
4-(Hydroxyamino)-4-oxobutanoic acid
Synonyma:
Tofacitinib Impurity 208;N-Hydroxysuccinamidic acid;4-(Hydroxyamino)-4-oxobutanoic acid;Butanoic acid, 4-(hydroxyamino)-4-oxo-;3-(Hydroxyaminocarbonyl)propionic acid
CBNumber:
CB02174169
Summenformel:
C4H7NO4
Molgewicht:
133.1
MOL-Datei:
4743-99-1.mol

4-(Hydroxyamino)-4-oxobutanoic acid Eigenschaften

Schmelzpunkt:
82-86 °C(Solv: acetonitrile (75-05-8))
Dichte
1.436±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
5.28±0.10(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

4-(Hydroxyamino)-4-oxobutanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

synthetische

To a refluxing solution of 5.0 gm (0.05 mole) of succinic anhydride in 100 ml of benzene is added a solution of 6.3 gm (0.05 mole) of O-ben- zylhydroxylamine in 20 ml of benzene. As soon as the addition has been completed, the reaction mixture is cooled, and the precipitated product is separated. Upon recrystallization from a benzene-methyl ethyl ketone mixture, 7.6 gm (68.2%) of N-benzyloxysuccinamic acid, m.p. 95-96°C isolated.
A suspension of 4.3 gm (0.0193 mole) of this intermediate and a stron- tium carbonate catalyst containing 5% palladium in methyl ethyl ketone is hydrogenated. Upon working up the reaction mixture, 1.45 gm (56.7%) of succinomonohydroxamic acid, m.p. 95-96°C is isolated.
Preparation of N-Hydroxysuccinamic Acid

4-(Hydroxyamino)-4-oxobutanoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-(Hydroxyamino)-4-oxobutanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 22)Lieferanten
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Shaanxi Dideu Medichem Co. Ltd
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Amadis Chemical Company Limited
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Bide Pharmatech Ltd. 400-164-7117 13681763483
product02@bidepharm.com China 41462 60
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939
shenlinxing@macklin.cn China 16166 55
Suzhou Crst Pharmatech Co., Ltd. 0512-62910395 17751098781
sales@crstpharma.com China 499 58

4743-99-1()Verwandte Suche:


  • 3-(Hydroxyaminocarbonyl)propionic acid
  • 4-(Hydroxyamino)-4-oxobutanoic acid
  • N-Hydroxysuccinamidic acid
  • Butanoic acid, 4-(hydroxyamino)-4-oxo-
  • Tofacitinib Impurity 208
  • 4743-99-1
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