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2,6-Diamino-1H-pyrimidin-4-on

2,4-Diamino-6-hydroxypyrimidine Struktur
56-06-4
CAS-Nr.
56-06-4
Bezeichnung:
2,6-Diamino-1H-pyrimidin-4-on
Englisch Name:
2,4-Diamino-6-hydroxypyrimidine
Synonyma:
1956-6-4;2,6-DIAMINOPYRIMIDIN-4-OL;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
CBNumber:
CB0174912
Summenformel:
C4H6N4O
Molgewicht:
126.12
MOL-Datei:
56-06-4.mol

2,6-Diamino-1H-pyrimidin-4-on Eigenschaften

Schmelzpunkt:
285-286 °C (dec.) (lit.)
Siedepunkt:
234.22°C (rough estimate)
Dichte
1.3659 (rough estimate)
Brechungsindex
1.7990 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
10.61±0.50(Predicted)
Aggregatzustand
Fine Crystalline Powder
Farbe
White to cream
Sensitive 
Light Sensitive
Merck 
14,2981
BRN 
125006
InChIKey
SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS Datenbank
56-06-4(CAS DataBase Reference)
NIST chemische Informationen
4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA chemische Informationen
2,6-Diamino-4(1H)-pyrimidinone (56-06-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 22-24/25-36-26
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29335995
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

2,6-Diamino-1H-pyrimidin-4-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemische Eigenschaften

White Solid

Verwenden

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

l?uterung methode

It recrystallises from H2O. [Beilstein 25 III/IV 3642.]

2,6-Diamino-1H-pyrimidin-4-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Guanidiniumnitrat Methylcyanacetat 2,4-DIAMINO-6-HYDROXY-PYRIMIDINE-5-CARBALDEHYDE 2,4-DIAMINO-6-FLUOROPYRIMIDINE Guanidiniumchlorid

Downstream Produkte

2,4-DIAMINO-6-MERCAPTOPYRIMIDINE 2,6-DIAMINO-4-METHOXY PYRIMIDINE Benzylphenylsulfid 2,4-Diamino-6-hydroxy-5-nitropyrimidine 2,4-DIAMINO-6-ETHOXYPYRIMIDINE 4-Pyrimidinol 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-5-(1-methylethyl)-

2,6-Diamino-1H-pyrimidin-4-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 538)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Anhui Ruihan Technology Co., Ltd 		+8617756083858
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Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695
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sales@nbinno.com CHINA 923 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd. 		18853181302
sale@chuangyingchem.com CHINA 5906 58

56-06-4(2,6-Diamino-1H-pyrimidin-4-on)Verwandte Suche:

  • 2,4-Diamino-6-hydroxypyrimidine,96%
  • TIMTEC-BB SBB004252
  • 2,4-DIAMINOPYRIMIDIN-6-OL
  • 2,4-DIAMINO-6-HYDROXYPYRIMIDINE
  • 2,4-DIAMINO-6-PYRIMIDINOL
  • 2,4-DIAMINO-6(1H)-PYRIMIDINONE
  • 2,6-DIAMINO-4-PYRIMIDINONE
  • 2,6-DIAMINO-4(1H)-PYRIMIDINONE
  • AURORA KA-376
  • AKOS MSC-0109
  • 2,6-Diamino-4-Hydroxyprimidine
  • 2-4-DIAMINO6HYDROXY PYRIMID
  • 2,4- two-6- aMinohydroxy pyriMidine
  • 2,4-DiaMino-6-hydroxypyriMidine 96%
  • 2,4-DiaMino-6-hydroxypyriMidine, 97+%
  • InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9
  • 2,4-Diamino-6-hydroxypyrimidiine
  • 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI)
  • 2,6-Diaminopyrimidin-4-one
  • 6-Aminoisocytosine
  • NSC 44914
  • NSC 680818
  • NSC 9302
  • 2,4-Diamino-6-hydroxy
  • 2,4-diaminohypoxanthine
  • 2,6-Diamino-1H-pyrimidin-4-on
  • 2,4-Diamino-6. -Hydroxypyimidine
  • 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE
  • 4(1H)-Pyrimidinone, 2,6-diamino
  • 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
  • 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol
  • 2,4-Diamino-6-pyrimidinone
  • 2,6-Diamino-3,4-dihydropyrimidine-4-one
  • 2,6-Diamino-4(3H)-pyrimidinone
  • 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
  • 4-DiaMino-6-hydroxypyriMidine
  • 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE
  • 6-Hydroxy-2,4-diaminopyrimidine
  • 2,4-Diamino-6-hydroxypyrimidine >
  • 2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH
  • 2,4-Diamino-6-hydroxypyrimidine,56-06-4
  • NSC 18522
  • NSC18522
  • NSC-18522
  • 3-methylidene-1,5-benzodioxepine
  • Pemetrexed Impurity 16
  • 2,6-DIAMINOPYRIMIDIN-4-OL
  • DAHP
  • 2,6-diamino-1H-pyrimidin-4-one
  • 4(3H)-pyrimidinone, 2,6-diamino-
  • 2,6-Diaminopyrimidin-4(1H)-one
  • 1956-6-4
  • Minoxidil Impurity 19
  • 2,6-DIAMINO-4-PYRIMIDINOL
  • 2,6-DIAMINO-4-HYDROXYPYRIMIDINE
  • 2,4-Diamino-6-hydroxypyrimidine(98.60%)
  • 9-60-9
  • 2.4-Diamino-6-pyrimidone
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