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fomivirsen

fomivirsen Struktur
160369-77-7
CAS-Nr.
160369-77-7
Englisch Name:
fomivirsen
Synonyma:
CBNumber:
CB01350113
Summenformel:
C204H243N63Na20O114P20S20
Molgewicht:
7122.03654
MOL-Datei:
160369-77-7.mol

fomivirsen Eigenschaften

storage temp. 
Store at -20°C
Aggregatzustand
Solid
Farbe
White to off-white

Sicherheit

fomivirsen Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fomivirsen Sodium was launched as Vitravene in the US and is indicated for the local treatment of cytomegalovirus (CMV)-induced retinitis in AIDS patients. It consists of a phosphorothioate oligonucleotide (PS) comprised of a sequence of 21 nucleotides. Fomivirsen is synthesized using solid-phase phosphoramidite chemistry. Fomivirsen inhibits human CMV replication by a antisense mechanism : it targets an immediate early mRNA of cytomegalovirus, inhibiting the expression of two regulatory proteins. Fomivirsen was the most advanced first-generation PS drug candidate in human clinical trials and was the first agent based on antisense technology to reach the market. In normal human dermal fibroblast cells, Fomivirsen inhibited AD169 human CMV replication by more than 90%, at a concentration of 5μM ; it showed greater hCMV replication inhibitor properties than ganciclovir in several experimental models.

Originator

Isis Pharmaceuticals (US)

Trademarks

Vitravene

fomivirsen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


fomivirsen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 5)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Cato Research Chemicals Inc. 13342851930
3008394369@qq.com China 15726 58

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