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7α,25-dihydroxy Cholesterol

7α,25-dihydroxy Cholesterol Struktur
64907-22-8
CAS-Nr.
64907-22-8
Englisch Name:
7α,25-dihydroxy Cholesterol
Synonyma:
7Α;7α,25-OHC;Cholesterol Impurity 33;25-dihydroxycholesterol;5-Cholesten-3β,7α,25-triol;7α,25-dihydroxy Cholesterol;7-alpha,25-Dihydroxycholesterol;3β,7α,25-Trihydroxycholest-5-ene;3β,7α,25-Trihydroxycholest-5-ene;(3β,7α)-Cholest-5-ene-3,7,25-triol
CBNumber:
CB01235638
Summenformel:
C27H46O3
Molgewicht:
418.65
MOL-Datei:
64907-22-8.mol

7α,25-dihydroxy Cholesterol Eigenschaften

Siedepunkt:
548.5±35.0 °C(Predicted)
Dichte
1.08±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble5mg/mL (clear solution)
Aggregatzustand
powder
pka
14.11±0.70(Predicted)
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

7α,25-dihydroxy Cholesterol Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.[Cayman Chemical]

Allgemeine Beschreibung

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7).

Biochem/physiol Actions

7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.

7α,25-dihydroxy Cholesterol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


7α,25-dihydroxy Cholesterol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 40)Lieferanten
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Creative Enzymes
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TargetMol Chemicals Inc.
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Shanghai Acmec Biochemical Technology Co., Ltd.
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Aladdin Scientific
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SHANGHAI KEAN TECHNOLOGY CO., LTD.
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Amadis Chemical Company Limited
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4674 55
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

  • 7-alpha,25-Dihydroxycholesterol
  • 3β,7α,25-Trihydroxycholest-5-ene
  • 5-Cholesten-3β,7α,25-triol
  • 25-dihydroxycholesterol
  • 7Α,25-DIHYDROXYCHOLESTEROL;7Α;25-DIHYDROXYCHOLESTEROL
  • (3β,7α)-Cholest-5-ene-3,7,25-triol
  • 7α,25-OHC
  • 7α,25-dihydroxy Cholesterol
  • Cholesterol Impurity 33
  • 3β,7α,25-Trihydroxycholest-5-ene
  • endogenous,response,oxysterols,Endogenous Metabolite,GPCR,EBI2/GPR183,ligand,7α,25 Dihydroxycholesterol,receptor,Inhibitor,immune,7α,25-Dihydroxycholesterol,migration,7α,25Dihydroxycholesterol,cells,inhibit
  • Cholest-5-ene-3,7,25-triol, (3β,7α)-
  • 64907-22-8
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