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BI-0474

BI-0474 Struktur
2750570-55-7
CAS-Nr.
2750570-55-7
Englisch Name:
BI-0474
Synonyma:
BI-0474;Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
CBNumber:
CB012245556
Summenformel:
C30H37N9O2S
Molgewicht:
587.74
MOL-Datei:
2750570-55-7.mol

BI-0474 Eigenschaften

Siedepunkt:
879.4±75.0 °C(Predicted)
Dichte
1.38±0.1 g/cm3(Predicted)
pka
7.13±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
CKAMBYUZKWQCKJ-ADSBAMQRSA-N
SMILES
C12CCC[C@@](C3ON=C(C4=NC(N5CCN(C)C[C@@H]5C)=CC(N5CCN(C(=O)C=C)CC5)=C4)N=3)(C)C=1C(C#N)=C(N)S2

Sicherheit

BI-0474 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.

BI-0474 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BI-0474 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Chuchang Biotech Co., Ltd.
+undefined15623860702
 info@chuchangbiotech.com China 211 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Hubei Chuchang Chemical Co., Ltd 18; 15623560702
 Joy.Ren@aliyun.com China 156 58
Changzhou Borl Biotechnology Co.,LTD 13606124132;13656121842
 luyan0021@163.com China 219 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4565 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901
 info@angtibio.com China 4997 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
 2853530910@QQ.com China 8010 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2987 58
  • Benzo[b]thiophene-3-carbonitrile, 2-amino-4-[3-[6-[(2S)-2,4-dimethyl-1-piperazinyl]-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-pyridinyl]-1,2,4-oxadiazol-5-yl]-4,5,6,7-tetrahydro-4-methyl-, (4S)-
  • BI-0474
  • 2750570-55-7
  • C30H37N9O2S
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