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Seneciphylline

Seneciphylline Struktur
480-81-9
CAS-Nr.
480-81-9
Englisch Name:
Seneciphylline
Synonyma:
JACODINE;NSC 30622;Aids002697;NCI-C-61165;Aids-002697;α-Longilobin;SENECIPHYLLIN;Seneciphynine;seneciphylline;seneciophylline
CBNumber:
CB0103055
Summenformel:
C18H23NO5
Molgewicht:
333.38
MOL-Datei:
480-81-9.mol

Seneciphylline Eigenschaften

Schmelzpunkt:
217°C
alpha 
D -128° (chloroform)
Siedepunkt:
470.34°C (rough estimate)
Dichte
1.2467 (rough estimate)
Brechungsindex
1.5740 (estimate)
storage temp. 
-20°C
L?slichkeit
DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml
pka
12.43±0.20(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
Stabilit?t:
Stable, but reacts with oxygen in the air. Incompatible with alkali, oxidizing agents. Store under inert gas.
LogP
0.810 (est)
CAS Datenbank
480-81-9
IARC
3 (Vol. 10, Sup 7) 1987
EPA chemische Informationen
Seneciphylline (480-81-9)

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25-25
S-S?tze: 1-20-24/25-45
RIDADR  1544
WGK Germany  3
HazardClass  6.1(b)
PackingGroup  III
Giftige Stoffe Daten 480-81-9(Hazardous Substances Data)

Seneciphylline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S1:Unter Verschluss aufbewahren.
S20:Bei der Arbeit nicht essen und trinken.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Seneciphylline, a pyrrolizidine alkaloid, one of the main components of Chinese medicine herb Tusanqi, which is a reason of the hepatic sinusoidal obstruction syndrome (HSOS). In addition, experiments on rats have shown that seneciphylline had adverse effects on the development and organic morphodifferentiation of embryos, thus the pregnant people exposed to Hebra may get potential risk on the fetus.

Chemische Eigenschaften

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, Derived from the whole plant or root of Gynura segetum (Lour.) Merr (Ju Sanqi).

Verwenden

Seneciphylline is a minor constituent of S. jacobaea, which has been used as a medicinal herb in Europe. It has the effect of coagulation and hemostasis.
Seneciphylline is a pyrrolizidine alkaloid with the potential to affect hepatic drug metabolizing enzymes in rat cells.

Air & Water Reaktionen

Reacts slowly with atmospheric oxygen. . Insoluble in water.

Reaktivit?t anzeigen

SENECIPHYLLIN is readily hydrolyzed with alkali; SENECIPHYLLIN reacts readily with oxidizing agents .

Health Hazard

Seneciphylline and aflatoxin B. may be of greater importance as a cause of human disease than the presently known outbreaks of poisoning would indicate.
SYMPTOMS: Symptoms associated with this compound include abdominal pain, nausea and diarrhea, emaciation, intestinal edema and congestion of the liver. ACUTE/CHRONIC HAZARDS: Very toxic. (NTP, 1992)

Brandgefahr

Flash point data are not available for SENECIPHYLLIN, but SENECIPHYLLIN is probably combustible.

Seneciphylline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Seneciphylline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 138)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Greenpure Biopharma CO.,Ltd
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Hebei Weibang Biotechnology Co., Ltd
+8615531157085
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Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Fengjia New Material Co., Ltd
+86-0311-87836622 +86-17333973358
sales06@hbduling.cn China 8051 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3772 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
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  • ALPHA-LONGILOBINE
  • SENECIPHYLLIN
  • (15cis)-12-Hydroxy-13,19-didehydrosenecionan-11,16-dione
  • 13,19-didehydro-12-hydroxysenecionan-11,16-dione
  • 16-dione,13,19-didehydro-12-hydroxy-senecionan-1
  • 16-dione,13,19-didehydro-12-hydroxy-senecionin-1
  • NSC 30622
  • oxy-6-methyl-5-methylene(1,6)dioxacyclodode///
  • Pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene(1,6)dioxacyclododecino(2,3,4-gh)-
  • pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydr
  • Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-
  • seneciophylline
  • seneciphylline
  • NCI-C-61165
  • Aids002697
  • Aids-002697
  • SENECIPHYLLIN(SG)
  • 3,19-Didehydro-12-hydroxysenecionan-11,16-dione
  • α-Longilobin
  • Seneciphynine
  • JACODINE
  • [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-,(3Z,6R,14aR,14bR)-
  • (6R,9a1R,14aR,Z)-3-Ethylidene-6-hydroxy-6-methyl-5-methylene-3,4,5,6,9,9a1,11,13,14,14a-decahydro-[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione
  • Seneciphylline in methanol
  • Seneciphyllin(AS)
  • Seneciphylline-RM
  • 480-81-9
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