Nelarabine
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- CAS-Nr.
- 121032-29-9
- Englisch Name:
- Nelarabine
- Synonyma:
- MAY;Arranon;Nelzarabine;506u;506U78;CS-1953;GW 506U78;NELARABIN;NELARABINE;Nelarabine D4
- CBNumber:
- CB01011878
- Summenformel:
- C11H15N5O5
- Molgewicht:
- 297.27
- MOL-Datei:
- 121032-29-9.mol
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Nelarabine Eigenschaften
- Schmelzpunkt:
- 209-217°
- alpha
- D20 +55.9° (c = 0.27 in DMF)
- Siedepunkt:
- 721.0±70.0 °C(Predicted)
- Dichte
- 1.98±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 13.07±0.70(Predicted)
- Farbe
- White
- InChI
- InChI=1/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/s3
- InChIKey
- IXOXBSCIXZEQEQ-GCTRTDOSNA-N
- SMILES
- N1(C=NC2C(OC)=NC(N)=NC1=2)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:12,13,15,17,r|
- CAS Datenbank
- 121032-29-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Nelarabine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nelarabine is a new member of the purine nucleoside antimetabolite class of
drugs. It was launched as an intravenous infusion for treating relapsed
or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic
lymphoma (T-LBL) after at least two prior chemotherapy regimens.
Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine
derivative with a high level of T-cell selective cytotoxicity. Although
Ara-G has been known since the 1960s, it has not been used in clinical studies
due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with
approximately 10 times greater aqueous solubility. It is demethylated in vivo by
adenosine deaminase to produce ara-G, which is subsequently converted to the
active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts
allows for incorporation into DNA, leading to inhibition of DNA synthesis and
cell death.
Verwenden
A chemotherapy drug used in the treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).
Definition
ChEBI: Nelarabine is a purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G). It has a role as an antineoplastic agent, a DNA synthesis inhibitor and a prodrug. It is a purine nucleoside, a beta-D-arabinoside and a monosaccharide derivative. It is functionally related to a guanine and a 9-beta-D-arabinofuranosylguanine.
Nelarabine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nelarabine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 251)Lieferanten
121032-29-9()Verwandte Suche:
- (2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
- 506U78
- (2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine
- NELARABINE
- Nelzarabine [USAN]
- 9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
- Nelarabine (Arranon)
- 506u
- 9-β-D-Arabinofuranosyl-6-Methoxy-9H-purin-2-aMine
- GW 506U78
- (2R,3R,4S,5R)-2-(2-aMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-tetrahydrofuran-3,4-diol
- NELARABIN
- 9H-Purin-2-aMine, 9-b-D-arabinofuranosyl-6-Methoxy-
- Nelarabine (506U78)
- Nelarabine USP/EP/BP
- Nelarabine D4
- CS-1953
- Nelzarabine
- Arranon
- MAY
- Nelarabine/Arranon/506U78
- 9H-Purin-2-amine, 9-β-D-arabinofuranosyl-6-methoxy-
- 121032-29-9
- 121032-29-2
- 1201032-29-9
- API
- Inhibitors
- 5g,10g,25g,100g
- ARRANON
- Anti-cancer&immunity
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Bases & Related Reagents
- 121032-29-9
