L-689,560
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- CAS號(hào):
- 139051-78-8
- 英文名:
- L-689,560
- 英文別名:
- L-689,560;TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE;4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline;2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-, (2R,4S)-rel-
- 中文名:
- L-689,560
- 中文別名:
- 化合物 T15684;化合物 L-689560;L-689,560,NMDA拮抗劑
- CBNumber:
- CB9236350
- 分子式:
- C17H15Cl2N3O3
- 分子量:
- 380.23
- MOL File:
- 139051-78-8.mol
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L-689,560化學(xué)性質(zhì)
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熔點(diǎn):
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172-173°C
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沸點(diǎn):
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549.1±50.0 °C(Predicted)
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密度:
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1.51±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at RT
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溶解度:
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<9.51mg/ml in DMSO; <38.02mg/ml in ethanol
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形態(tài):
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solid
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酸度系數(shù)(pKa):
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11.16±0.20(Predicted)
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顏色:
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White
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L-689,560性質(zhì)、用途與生產(chǎn)工藝
L-689560 是一種有效的 N-甲基-D-天冬氨酸 (NMDA) 受體拮抗劑，抑制 GluN1 甘氨酸結(jié)合位點(diǎn)。L-689560 在廣泛用作結(jié)合研究中的放射性標(biāo)記配體，也用來研究 NMDA 受體在正常神經(jīng)系統(tǒng)過程以及疾病中的作用。
L-689560 is a 2-carboxytetrahydroquinoline antagonist.
L-689560 (1?mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model
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Animal Model:
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Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model
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Dosage:
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1?mg/kg
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Administration:
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IP
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Result:
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Significantly reduced the neuroprotective effect of glycine after glycine receptors.
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L-689,560
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-101178 | L-689560 | | 1 mg | 1450元 |
| 2024/11/08 | HY-101178 | L-689,560
L-689560 | 139051-78-8 | 5mg | 3800元 |
139051-78-8, L-689,560 相關(guān)搜索:
- 抑制劑
- C17H15N3O3Cl2
- 化合物 L-689560
- L-689,560,NMDA拮抗劑
- 化合物 T15684
- 139051-78-8
- 2-Quinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-4-[[(phenylamino)carbonyl]amino]-, (2R,4S)-rel-
- 4-trans-2-carboxy-5,7-dichloro-4-phenylaminocarbonylamino-1,2,3,4-tetrahydroquinoline
- TRANS-2-CARBOXY-5,7-DICHLORO-4-PHENYLAMINOCARBONYLAMINO-1,2,3,4-TETRAHYDROQUINOLINE
- L-689,560