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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. L-689560

L-689560 是一種有效的 N-甲基-D-天冬氨酸 (NMDA) 受體拮抗劑，抑制 GluN1 甘氨酸結(jié)合位點(diǎn)。L-689560 在廣泛用作結(jié)合研究中的放射性標(biāo)記配體，也用來研究 NMDA 受體在正常神經(jīng)系統(tǒng)過程以及疾病中的作用。

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L-689560 Chemical Structure

L-689560 Chemical Structure

CAS No. : 139051-78-8

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1450
In-stock
5 mg ￥3800
In-stock
10 mg   詢價  
50 mg   詢價  

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查看 iGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].

體外研究
(In Vitro)

L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

L-689560 (1?mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1]
Dosage: 1?mg/kg
Administration: IP
Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors.
分子量

380.23

Formula

C17H15Cl2N3O3
CAS 號
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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產(chǎn)品名稱：
L-689560
目錄號：
HY-101178
需求量：