利拉利汀鈉鹽
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- CAS號:
- 148554-65-8
- 英文名:
- SECO RAPAMYCIN SODIUM SALT
- 英文別名:
- Secosirolimus;Secorapamycin Na salt;SECORAPAMYCIN A MONOSODIUM;SECO RAPAMYCIN SODIUM SALT;seco Rapamycin Sodium Salt, >85% By HPLC;(19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC);(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
- 中文名:
- 利拉利汀鈉鹽
- 中文別名:
- 色拉帕霉素;利拉利汀鈉鹽;山高雷帕霉素鈉鹽;化合物 T19558;SECO雷帕霉素鈉鹽;(19E/Z)-SECO RAPAMYCIN SODIUM SALT (~80% BY HPLC)
- CBNumber:
- CB4501000
- 分子式:
- C51H80NNaO13
- 分子量:
- 938.18
- MOL File:
- 148554-65-8.mol
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利拉利汀鈉鹽化學(xué)性質(zhì)
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熔點:
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120-122°C
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儲存條件:
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Amber Vial, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形態(tài):
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Solid
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顏色:
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Pale Yellow to Yellow
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穩(wěn)定性:
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Light Sensitive
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利拉利汀鈉鹽性質(zhì)、用途與生產(chǎn)工藝
Seco Rapamycin sodium salt 是 Rapamycin 的開環(huán)代謝物。Seco-Rapamycin 幾乎不影響 mTOR 功能。
Disposition of Seco Rapamycin in Human Tissue Homogenates and Caco-2 Cell Monolayers. To determine whether Seco Rapamycin (D2) can be metabolized to dihydro Sirolimus (M2), 20 μM Seco Rapamycin is incubated with human liver, jejunal mucosal, and Caco-2 homogenates. All of these homogenates produced M2 in an NADPH-dependent manner. Ketoconazole, at a high concentration (100 μM), has no effect on the formation of M2 in any of the homogenates examined. To determine whether Seco Rapamycin can be metabolized to M2 in intact cells, 20 μM Seco Rapamycin is added to Caco-2 cell monolayers. When applied to the apical compartment, little Seco Rapamycin is detected in the basolateral compartment and in the cellular fraction after 4 h. In addition, little M2 is detected. LY335979 has little effect on the distribution of Seco Rapamycin after an apical dose, although M2 became detectable in the apical compartment. In contrast, when Seco Rapamycin is applied to the basolateral compartment, both Seco Rapamycin and M2 are readily detected in the apical compartment; LY335679 decreases the flux of Seco Rapamycin to the apical compartment and increases the amount of M2 in both apical and basolateral compartments.
利拉利汀鈉鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/02/08 | HY-19555A | 利拉利汀鈉鹽
Seco Rapamycin sodium salt | 148554-65-8 | 1 mg | 1590元 |
| 2025/02/08 | HY-19555A | 利拉利汀鈉鹽
Seco Rapamycin sodium salt | 148554-65-8 | 5mg | 3500元 |
148554-65-8, 利拉利汀鈉鹽 相關(guān)搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Impurities
- Heterocycles
- Chiral Reagents
- Various Metabolites and Impurities
- Metabolites & Impurities
- 抑制劑
- C51H78NNaO13
- 山高雷帕霉素鈉鹽
- 色拉帕霉素
- 化合物 T19558
- SECO雷帕霉素鈉鹽
- 利拉利汀鈉鹽
- (19E/Z)-SECO RAPAMYCIN SODIUM SALT (~80% BY HPLC)
- 148554-65-8
- Secosirolimus
- Secorapamycin Na salt
- (19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC)
- (19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
- SECORAPAMYCIN A MONOSODIUM
- SECO RAPAMYCIN SODIUM SALT
- seco Rapamycin Sodium Salt, >85% By HPLC