地拉卓二鹽酸鹽
|
|
|
- CAS號(hào):
- 20153-98-4
- 英文名:
- DILAZEP DIHYDROCHLORIDE
- 英文別名:
- cormelian;astac;k-285;C12954;C-4898;labitan;comelian;astac4898;Delazeol Hydrochloride;DILAZEP DIHYDROCHLORIDE
- 中文名:
- 地拉卓二鹽酸鹽
- 中文別名:
- 鹽酸地拉卓;地拉卓二鹽酸鹽;地拉卓二鹽酸鹽,10 MM DMSO 溶液;1,4-雙[3-(3,4,5-三甲氧基苯甲酰氧基)丙基]高哌嗪二鹽酸鹽;(1,4-二氮雜環(huán)庚烷-1,4-二基)雙(丙烷-3,1-二基) 雙(3,4,5-三甲氧基苯甲酸酯) 二鹽酸鹽
- CBNumber:
- CB2143031
- 分子式:
- C31H46Cl2N2O10
- 分子量:
- 677.61
- MOL File:
- 20153-98-4.mol
|
|
|
地拉卓二鹽酸鹽化學(xué)性質(zhì)
-
熔點(diǎn):
-
194-198° (monohydrate)
-
|
-
儲(chǔ)存條件:
-
2-8°C
-
|
-
溶解度:
-
H2O: 10 mg/mL
-
|
-
形態(tài):
-
powder
-
|
-
顏色:
-
white
-
|
-
水溶解性:
-
Soluble to 100 mM in water
-
|
地拉卓二鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
Dilazep dihydrochloride 是腺苷攝取的抑制劑。Dilazep dihydrochloride 通過(guò)增強(qiáng)腺苷的作用而具有腦和冠狀血管舒張作用。Dilazep dihydrochloride 還可抑制缺血性損傷，血小板聚集和核苷的膜轉(zhuǎn)運(yùn)。
The uptake mechanism has been studied extensively in vitro and Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. Of these compounds, Dilazep and NBI are almost 10 times more potent than Dipyridamole. In addition, only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution.
After administration of Dilazep, even low doses (0.04-0.1 mg/kg/min) of exogenous adenosine significantly increases superior mesenteric arterial conductance (SMAC) and elevates arterial plasma adenosine concentration. The increased adenosine levels were highly correlated with the increased percentage of change of SMAC and values for R
max
and EC
50
were 193.4% change of SMAC and 2.8 μM, respectively. Administration of bolus doses of 8-phenyltheophylline abolishes the ability of Dilazep to potentiate vasodilation, but did not affect isoproterenol-induced relaxation.
Dilazep inhibits the phospholipase activation in reperfused heart mitochondria and also inhibits the lipid peroxidation caused by cerebral ischemia and reperfusion. Dilazep may prevent ischemic cerebral injury due to an increase in cerebral blood flow and/or its protective effects on vascular endothelial cell membrane.
地拉卓二鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
地拉卓二鹽酸鹽
生產(chǎn)廠(chǎng)家
20153-98-4, 地拉卓二鹽酸鹽 相關(guān)搜索:
3,4-二甲氧基-5-羥基苯甲酸 3,4-二羥基-5-甲氧基苯甲酸甲酯 3,4,5-三甲氧基苯甲酸乙酯 丁香酸 3,4-二羥基苯甲酸乙酯 海索苯定 1-乙基高哌嗪 丁香酸甲酯 3,5-二甲氧基苯甲酸 雙酯嗪 3,5-二羥基苯甲酸甲酯 甲基-Β-D-吡喃半乳糖苷 3,4,5-三甲氧基苯甲酸 沒(méi)食子酸丙酯 3,4,5-三甲氧基苯甲酸甲酯 3,5-二乙氧基基苯甲酸甲酯 3,4-二甲氧基-5-羥基苯甲酸甲酯 高哌嗪
- 抑制劑
- 藥靶配體
- C31H44N2O102HCl
- C31H46N2O102Cl
- 地拉卓二鹽酸鹽,10 MM DMSO 溶液
- 鹽酸地拉卓
- (1,4-二氮雜環(huán)庚烷-1,4-二基)雙(丙烷-3,1-二基) 雙(3,4,5-三甲氧基苯甲酸酯) 二鹽酸鹽
- 1,4-雙[3-(3,4,5-三甲氧基苯甲酰氧基)丙基]高哌嗪二鹽酸鹽
- 地拉卓二鹽酸鹽
- 20153-98-4
- Dilazep dihydrochloride, 10 mM in DMSO
- Delazeol Hydrochloride
- ischemic,Adenosine,Dilazep dihydrochloride,uptake,vasodilation,potentiate,Inhibitor,cerebral,damage,inhibit,Dilazep
- cormelian
- (1,4-diazepane-1,4-diyl)bis(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
- labitan
- ASTA C 4898, Cormelian, N,Nμ-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride
- DILAZEP DIHYDROCHLORIDE (COMELIAN, CORME LIAN, ASTA C) \ ADENOSINE UPTAKE INHIB
- (tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di(propane-1,3-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
- n,n’-(bis-omega-hydroxypropyl)homopiperazine3,4,5-trimethoxybenzoatedihydro
- k-285
- h)dipropanol,dihydrochloride
- C12954
- C-4898
- comelian
- benzoicacid,3,4,5-trimethoxy-,diesterwithtetrahydro-1h-1,4-diazepine-1,4(5
- astac4898
- astac
- 1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)perhydro-1,4-diazepinedihydroc
- N,N'-BIS[3-(3,4,5-TRIMETHOXY-BENZOYLOXY)PROPYL]HOMOPIPER-AZINE DIHYDROCHLORIDE
- 1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE
- DILAZEP DIHYDROCHLORIDE