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99119-73-0

中文名稱 苦參醇C
CAS 99119-73-0
分子式 C25H26O7
分子量 438.47
MOL 文件 99119-73-0.mol
99119-73-0 結(jié)構(gòu)式 99119-73-0 結(jié)構(gòu)式

基本信息

中文別名
苦參醇C
苦參新醇 C
英文別名
Kushenol C
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-

常見問題列表

生物活性
Kushenol C 是從苦參根中分離出來的,具有抗炎和抗氧化的作用。Kushenol C 抑制 BACE1 的 IC50 值為 5.45 μM。
體外研究

Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 μM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells.
Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells.
Kushenol C inhibits BChE and AChE with IC 50 s of 54.86 and 33.13 μM.

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