101236-49-1
101236-49-1 結構式
基本信息
中文別名
苦參醇K苦參醇K對照品
苦參醇K標準品
英文別名
Kushenol Kproduct/154906
(2R,3S)-2-(2,4-Dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(1-methylethenyl)hexyl]-5-methoxy-, (2R,3S)-
常見問題列表
生物活性
Kushenol K，一種從 Sophora flavescens 中提取的黃酮類抗氧化劑。Kushenol K 是 CYP3A4 的抑制劑，Ki 值為 1.35 μM。Kushenol K 對 HSV-2 具有較弱的抗病毒活性 (EC50 為 147 μM)。Kushenol K 還抑制 SGLT1 和 SGLT2 的活性。靶點
|
HSV-2 147 μM (EC 50 ) |
CYP3A4 1.35 μM (Ki) |
SGLT
|
體外研究
When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC
50
values of 1.62 μM.
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%.