99-32-1
99-32-1 結(jié)構(gòu)式
基本信息
γ-吡喃酮-2,6-二羧酸
白菜酸
白屈菜酸
4-吡喃酮-2,6-二羧酸
AKOS AUF02028
CHELIDONIC ACID
GAMMA-PYRONE-2,6-DICARBOXYLIC ACID
G-PYRONE-2,6-DICARBOXYLIC ACID
JERVA ACID
JERVASIC ACID
TIMTEC-BB SBB000242
4-oxo-1,4-pyran-2,6-dicarboxylicacid
4-oxo-4h-pyran-6-dicarboxylicacid
6-dicarboxylicacid,4-oxo-4H-Pyran-2
compoundxi*
jervaicacid
-Pyrone-2,6-dicarboxylicacid
CHELIDONIC ACID, ANHYDROUS
AI3-19253
CHELIDONIC ACID(RG)
PYRAN-2,6-DICARBOXYLICACID,4-OXO-
4-Oxopyran-2,6-dicarboxylic acid
4-Pyranone-2,6-dicarboxylic acid
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/11 | XW9932101 | 白屈菜酸 | 99-32-1 | 1G | 69元 |
| 2024/11/08 | HY-W041489 | 白屈菜酸 Chelidonic acid | 99-32-1 | 100mg | 600元 |
| 2024/11/08 | HY-W041489 | 白屈菜酸 Chelidonic acid | 99-32-1 | 10mM * 1mLin DMSO | 660元 |
常見問題列表
白屈菜酸(Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在幾種植物中發(fā)現(xiàn)的次級代謝產(chǎn)物，對實驗動物的過敏性疾病具有治療潛力。Chelidonic acid 通過阻斷HMC-1細胞中的 NF-κB 和 caspase-1 來抑制 IL-6 的產(chǎn)生。Chelidonic acid 也是 glutamate decarboxylase 的抑制劑，其Ki值為1.2 μM。
| Target | Value |
|
NF-κB
() | |
|
Caspase-1
() | |
|
IL-6
() | |
|
glutamate decarboxylase
() |
Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM.
Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation.
Chelidonic acid is a glutamate decarboxylase inhibitor, with a K
i
of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P.
Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.