90614-48-5
中文名稱
抑二肽素A
英文名稱
DIPROTIN A
CAS
90614-48-5
分子式
C17H31N3O4
MDL 編號(hào)
MFCD00038707
分子量
341.45
MOL 文件
90614-48-5.mol
更新日期
2024/12/18 11:18:05
90614-48-5 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)583.1±50.0 °C(Predicted)
密度1.140±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度DMSO:250.0(Max Conc. mg/mL);732.17(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
酸度系數(shù)(pKa)3.72±0.22(Predicted)
形態(tài)白色至類白色固體
顏色White to off-white
水溶解性Soluble in water at 1mg/ml
CAS 數(shù)據(jù)庫(kù)90614-48-5(CAS DataBase Reference)
常見問題列表
生物活性
Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制劑。靶點(diǎn)
IC50: DPP-IV
體外研究
Diprotin A (100?μM; 30?minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.
Western Blot Analysis
| Cell Line: | Human endothelial cells [1] |
| Concentration: | 100?μM |
| Incubation Time: | 30?minutes after CXCR4-blocker or Src-inhibitor treatment |
| Result: | Induced the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs. |
體內(nèi)研究
Diprotin A (intraperitoneal injection; 70?μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
| Animal Model: | Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice |
| Dosage: | 70?μg/kg |
| Administration: | Intraperitoneal injection; twice daily; 7 days |
| Result: | Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. |