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89750-14-1

中文名稱 glucagon-like peptide 1
英文名稱 glucagon-like peptide 1
CAS 89750-14-1
分子式 C149H226N40O45
分子量 3297.63
MOL 文件 89750-14-1.mol
更新日期 2024/12/22 20:23:41
89750-14-1 結(jié)構(gòu)式 89750-14-1 結(jié)構(gòu)式

基本信息

中文別名
重組人胰高血糖激素樣多肽-1(7-36)
英文別名
glucagon-like peptide 1
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

序列H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

應(yīng)用領(lǐng)域

用途一
GLP-1 stimulates pancreatic β cells to secrete insulin as an incretin hormone. GLP-1 also has additional actions, including suppression of glucagon secretion, inhibition of gastric motility, and promotion of satiety. GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP-1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.
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