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84687-45-6

中文名稱 黃芪皂苷VI
英文名稱 Astragaloside VI
CAS 84687-45-6
分子式 C47H78O19
分子量 947.11
MOL 文件 84687-45-6.mol
更新日期 2024/12/20 18:42:48
84687-45-6 結(jié)構(gòu)式 84687-45-6 結(jié)構(gòu)式

基本信息

中文別名
黃芪皂苷VI
黃芪皂苷VI 黃芪皂苷X2
英文別名
Astragaloside VI
β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-3-[(2-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl
(3beta,6alpha,16beta,20R,24S)-20,24-Epoxy-3-[(2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside
所屬類別
生物化工:植物提取物

物理化學(xué)性質(zhì)

密度1.46±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)12.89±0.70(Predicted)
形態(tài)Solid
顏色White to yellow

常見問題列表

生物活性
Astragaloside VI 可通過激活表皮生長因子受體/細(xì)胞外信號調(diào)節(jié)激酶 (EGFR/ERK) 信號通路來加速傷口愈合。
靶點(diǎn)

EGFR

體外研究

Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades.

體內(nèi)研究

Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats.

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