80734-02-7
中文名稱(chēng)
鹽酸侖氨西林
英文名稱(chēng)
LENAMPICILLIN HYDROCHLORIDE
CAS
80734-02-7
分子式
C21H23N3O7S
分子量
461.49
MOL 文件
80734-02-7.mol
80734-02-7 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15734 英文別名
kb1585kbt1585
kbt-1585
varacillin
takacillin
LENAMPICILLIN
LenampicillinHCl
KBT-1585 HYDROCHLORIDE
Lempicillin hydrochloride
Lenanpicillin hydrochloride
所屬類(lèi)別
有機(jī)原料：羧酸類(lèi)化合物及衍生物物理化學(xué)性質(zhì)
熔點(diǎn)145° (dec)
儲(chǔ)存條件Store at -20°C, sealed storage, away from moisture and light
溶解度DMSO:100.0(Max Conc. mg/mL);200.82(Max Conc. mM)
形態(tài)Solid
顏色White to off-white
安全數(shù)據(jù)
毒性LD50 in male, female rats, male, female mice (mg/kg): approx 10000, approx 10000, 8294, 8492 orally; 4362, 4471, 3576, 4284 s.c.; 876, 838, 711, 775 i.v.; in dogs (mg/kg): >300 orally (Ogino)
鹽酸侖氨西林價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100500 | 鹽酸侖氨西林 Lenampicillin hydrochloride | 80734-02-7 | 5mg | 2800元 |
| 2024/11/08 | HY-100500 | 鹽酸侖氨西林 Lenampicillin hydrochloride | 80734-02-7 | 10mg | 4800元 |
常見(jiàn)問(wèn)題列表
生物活性
Lenampicillin hydrochloride (KBT 1585 hydrochloride) 是氨芐西林的口服前藥，是一種有效的-內(nèi)酰胺類(lèi)抗菌(beta-lactam antibacterial) 劑，可抑制細(xì)菌的青霉素結(jié)合蛋白(轉(zhuǎn)肽酶)。與氨芐西林相比，Lenampicillin 有改善吸收、減少副作用的作用，并應(yīng)用于化膿性皮膚軟組織感染的研究。靶點(diǎn)
IC50: bacterial penicillin-binding proteins (transpeptidase)
體內(nèi)研究
Lenampicillin hydrochloride (KBT-1585)?(oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.