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80321-69-3

中文名稱(chēng) 七葉膽苷XVII
英文名稱(chēng) GYPENOSIDE-XVII
CAS 80321-69-3
分子式 C48H82O18
分子量 947.15
MOL 文件 80321-69-3.mol
更新日期 2024/12/19 21:32:02
80321-69-3 結(jié)構(gòu)式 80321-69-3 結(jié)構(gòu)式

基本信息

中文別名
七葉膽苷ⅩⅦ
七葉膽苷XVI
七葉膽苷XVⅡ
七葉膽苷XVII
絞股藍(lán)皂甙XVII
絞股藍(lán)皂苷XVII
七葉膽皂苷XVII
七葉膽苷XVII對(duì)照品,
七葉膽苷XVII(標(biāo)準(zhǔn)品)
七葉膽苷XVII(絞股藍(lán)皂苷XVII)
英文別名
GP-17
Gynosaponin S
Gypenoside ⅩⅦ
GYPENOSIDE-XVII
Gypenoside XVII (Gynosaponin S)
3β-(β-D-Glucopyranosyloxy)-12β-hydroxy-5α-dammar-24-en-20-yl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,12β)-3-(β-D-glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-β-D-glucopyranosyl-
(3beta,12beta)-3-(beta-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
所屬類(lèi)別
生物化工:植物提取物

物理化學(xué)性質(zhì)

外觀(guān)性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來(lái)源于絞股藍(lán)(七葉膽)Fiveleaf Gynostemma Herb。
熔點(diǎn)>183°C (dec.)
沸點(diǎn)1013.5±65.0 °C(Predicted)
密度1.38
儲(chǔ)存條件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度DMSO(微量)、甲醇(微量)、吡啶(微量)
酸度系數(shù)(pKa)12.90±0.70(Predicted)
形態(tài)固體
顏色白色至灰白色
穩(wěn)定性吸濕性

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:絞股藍(lán)總皂甙具有人參皂甙的適應(yīng)原作用,其藥理作用大致可分為如下方面:1、消炎,抗腸、胃潰瘍和腫瘍。2、防癌抗癌。3、活化人體正常細(xì)胞(起增強(qiáng)體力、活力、耐力、恢復(fù)疲勞和延長(zhǎng)壽命的作用)。4、鎮(zhèn)靜和寧神。5、調(diào)節(jié)類(lèi)脂代謝。
用途2
七葉膽苷XVII是一種天然產(chǎn)物。

常見(jiàn)問(wèn)題列表

生物活性
Gypenoside XVII 是一種屬于絞股藍(lán)皂甙類(lèi)的新型植物雌激素,可激活雌激素受體 (estrogen receptors)。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

The ability of Gypenoside XVII (GP-17) to prevent Ox-LDL-induced cytotoxicity is detected by cell viability assays. Gypenoside XVII does not demonstrate any cytotoxicity in HUVECs. Gypenoside XVII can protect HUVECs against Ox-LDL-induced apoptosis. Gypenoside XVII dose-dependently mitigates the toxic effect of Ox-LDL on HUVEC viability. The viability of HUVECs is significantly higher than that of other groups at 50 μg/mL Gypenoside XVII .

體內(nèi)研究

Body weights are measured as physical measures of hormone bioactivity. Mean body weights are significantly higher in every group compared to that of the control, but there is no significant difference in body weight between the different treatments during the 10-week feeding. The mouse plasma lipid levels are also measured at the end of 10 weeks of a high-fat diet. Circulating levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are significantly increased in the treated groups of ApoE -/- mice compared with those of the C57BL/6J control group; Gypenoside XVII (GP-17) and Probucol treatment substantially decreases both of these parameters relative to those of the ApoE -/- model group.

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