7759-35-5
中文名稱
醋酸烯諾孕酮
英文名稱
Nestoron
CAS
7759-35-5
分子式
C23H30O4
分子量
370.48
MOL 文件
7759-35-5.mol
更新日期
2024/11/21 15:07:59
7759-35-5 結(jié)構(gòu)式
基本信息
中文別名
醋酸烯諾孕酮醋酸烯諾孕酮(ST-1435)
英文別名
ST 1435NESTORON
NESTORONE
Elcometrine
Nestoron (ST-1435)
Segesterone Acetate
ELCOMETRINE
NESTORONE
ST-1435
ST1435
ELCOMETRINE
NESTORONE
ST-1435
ST 1435
ST1435
17-(ACETYLOXY)-16-METHYLENE-19-NORPREGN-4-ENE-20-DIONE
17-(Acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)178-179°
比旋光度D21 -105° (c = 1.2 in chloroform)
沸點(diǎn)420.37°C (rough estimate)
密度1.0550 (rough estimate)
折射率1.4433 (estimate)
儲(chǔ)存條件2-8°C
溶解度DMSO：可溶，5mg/mL，澄清
形態(tài)粉末
顏色白色至米色
InChIKeyCKFBRGLGTWAVLG-GOMYTPFNSA-N
常見問題列表
生物活性
Nestoron (ST-1435) 是一種 19-norprogesterone 衍生物，對(duì) progesterone receptors 具有高親和力和選擇性，是一種高度選擇性和有效的孕激素，可用作激素避孕藥。靶點(diǎn)
Progesterone Receptors
體內(nèi)研究
Nestoron (400 μCi 3 H Nestoron/kg BW; subcutaneous injection; female Sprague-Dawley rats) treatment results in the C max in the blood and plasma are 58.1 and 95.5 ng equiv. 3 H Nestoron/g, with t 1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose is excreted via feces and urine, respectively.
| Animal Model: | 27 adult, female, Sprague-Dawley rats (200-225 g; age: 8 weeks) |
| Dosage: | 400 μCi 3 H Nestorone/kg BW |
| Administration: | Subcutaneous injection (Pharmacokinetic study) |
| Result: | The mean peak concentrations of radioactivity (C max ) in the blood and plasma were 58.1 and 95.5 ng equiv./g, with t 1/2 of 15.6 hours. Approximately, 81.4% and 7.62% of the administered dose was excreted via feces and urine, respectively. |