75567-37-2
基本信息
巨大戟醇-3-當(dāng)歸酸酯
巨大戟醇-3-O-當(dāng)歸酸酯
巨大戟醇甲基丁烯酸酯, >98%
巨大戟醇-3-O-當(dāng)歸酸酯(巨大戟醇甲基丁烯酸酯)
Ingenol mebutate
Ingenol 3-mebutate
Ingenol-3-O-angelate
Ingenol Mebutate, >98%
Ingenol Mebutate (PEP005)
Ingenol mebutate USP/EP/BP
PEP005
INGENOL MEBUTATE
I3A
Ingenol-3-O-angelate 75567-37-2
Ingenol-3-angelate Ingenol Mebutate
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2024/11/08 | HY-B0719 | 巨大戟醇-3-O-當(dāng)歸酸酯 Ingenol Mebutate | 75567-37-2 | 1mg | 868元 |
2024/11/08 | HY-B0719 | 巨大戟醇-3-O-當(dāng)歸酸酯 Ingenol Mebutate | 75567-37-2 | 10mM * 1mLin DMSO | 2586元 |
2024/11/08 | HY-B0719 | 巨大戟醇-3-O-當(dāng)歸酸酯 Ingenol Mebutate | 75567-37-2 | 5mg | 2730元 |
常見問題列表
PKC-β 0.105 nM (Ki) |
PKC-γ 0.162 nM (Ki) |
PKC-ε 0.171 nM (Ki) |
PKC-α 0.3 nM (Ki) |
PKC-δ 0.376 nM (Ki) |
Ingenol Mebutate (Ingenol 3-angelate) is an active ingredient in Euphorbia peplus , acting as a potent PKC activator, with K i s of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively. Ingenol Mebutate also EC 50 s of 13 ± 2.4 nM (PKC-α), 4.37 ± 0.4 nM (PKC-βI), 10.5 ± 2.2 nM (PKC-βII), 38.6 ± 2.9 nM (PKC-δ), 1.08 ± 0.01 nM (PKC-ε), 0.9 ± 0.13 nM (PKC-μ) in WEHI-231 cells, 198 ± 12.5 nM (PKC-α), 69.1 ± 8.2 nM (PKC-βI), 4.6 ± 0.4 nM (PKC-ε) and 1 nM (PKC-μ) in HOP-92 cells, 635 ± 245 nM (PKC-α), 146 ± 35 nM (PKC-βI), 4.7 ± 0.7 nM (PKC-δ), 1.1 ± 0.5 nM (PKC-ε), and 30 nM (PKC-μ) in Colo-205 cells. Ingenol Mebutate sensitizes WEHI-231 cells, HOP-92 and Colo-205 cells, with IC 50 s of 1.41 ± 0.255 nM, 3.24 ± 2.01 nM, and 11.9 ± 1.307 nM, respectively. Ingenol Mebutate (PEP005; 20 nM) actions are PKC-δ dependent, induces apoptosis in primary AML marrow blasts but not in normal myeloblasts. Ingenol Mebutate (PEP005) activates PKCδ and inhibits PKCα. Colo205-R cells (IC 50 : >10 μM) are >300-fold more resistant to Ingenol Mebutate than parental Colo205-S cells.