74805-92-8
中文名稱
麥冬高異黃酮A
英文名稱
Methylophiopogonanone A
CAS
74805-92-8
分子式
C19H18O6
分子量
342.34
MOL 文件
74805-92-8.mol
更新日期
2024/12/25 17:21:37
74805-92-8 結(jié)構(gòu)式
基本信息
中文別名
麥冬高異黃酮A麥冬甲基黃烷酮A
甲基麥冬黃烷酮A
甲基麥冬二氫高異黃酮A
麥冬高異黃酮A,甲基麥冬黃烷酮A
甲基麥冬二氫高異黃酮A(麥冬高異黃酮A
甲基麥冬二氫高異黃酮A,甲基麥冬黃烷酮A
甲基麥冬二氫高異黃酮A(麥冬高異黃酮A,甲基麥冬黃烷酮A)
英文別名
Methylophiopogonanone AR-Methylophiopogonanone A
8-Methylophiopogonanone A
Methylophiopogonanone A (MO-A)
Methylophiopogonanone A(R-Methylophiopogonanone A)
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
(3R)-3-(1,3-Benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-
所屬類別
天然產(chǎn)物：黃酮類化合物物理化學(xué)性質(zhì)
外觀性狀可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于麥冬須根Ophiopogon japonicus．。
沸點(diǎn)580.1±50.0 °C(Predicted)
密度1.410
溶解度Soluble in chloroform and methanol;
酸度系數(shù)(pKa)8.24±0.40(Predicted)
形態(tài)粉末
顏色淡黃色
水溶解性不溶于水
常見(jiàn)問(wèn)題列表
生物活性
Methylophiopogonanone A 是從 Ophiopogon japonicas 提取到的黃酮類化合物，具有抗氧化和抗炎作用。體外研究
Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L).
體內(nèi)研究
Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury.