74389-68-7
74389-68-7 結(jié)構(gòu)式
基本信息
C16PAF
ACGEPC
PAF (C16)
C16-02:0 PC
PAF (C16),99%
C16-PAF-acether
C16 ENANTIOMERIC PAF
PLATELET ACTIVATING FACTOR
PLATELET ACTIVATING FACTOR-16
物理化學性質(zhì)
安全數(shù)據(jù)
常見問題列表
|
Human Endogenous Metabolite
|
ERK
|
MEK
|
C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) elicits significant concentration-dependent neuronal loss in PAFR
?/?
but not PAFR
+/+
cultures. C16-PAF (1 μM) elicits neuronal death in PAFR
?/?
cells infected with EGFP alone.
C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3 in PAFR
?/?
neurons.
C16-PAF is synthesized by two distinct pathways; the remodeling pathway and the de novo synthesis pathway. C16-PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor.
C16-PAF (1-25 μg/ml; 6, 12, 24 h) inhibits
M. smegmatis
and
M. bovis
BCG growth in a time-dependent manner.
Cell Viability Assay
| Cell Line: | Cerebellar granule neurons (CGNs) from PAFR ?/? and PAFR +/+ mice |
| Concentration: | 0.5-1.5 μM |
| Incubation Time: | 24 hours |
| Result: | Elicited significant concentration-dependent neuronal loss in PAFR ?/? but not PAFR +/+ cultures in serum-free media. |
Western Blot Analysis
| Cell Line: | CGNs |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours |
| Result: | Activated caspase 7 but not caspase 3 in PAFR ?/? neurons. |