73208-40-9
73208-40-9 結(jié)構(gòu)式
常見問題列表
生物活性
Rp-cAMPS，一種 cAMP 的類似物，是一種 cAMP 誘導(dǎo)的 PKA I 和 PKA II 活化 (Ki 分別為 12.5 μM 和 4.5 μM) 的有效的，競爭性拮抗劑。Rp-cAMPS 耐磷酸二酯酶水解。靶點(diǎn)
Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)
體外研究
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
體內(nèi)研究
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.