151837-09-1
中文名稱
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
英文名稱
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
CAS
151837-09-1
分子式
C16H27N6O5PS
分子量
446.46
MOL 文件
151837-09-1.mol
151837-09-1 結(jié)構(gòu)式
基本信息
中文別名
(R)-腺苷 環(huán)3',5'-(硫代磷酸氫酯)三乙胺鹽 英文別名
RP-CAMPS TEACAMPS TEA, RP-ISOMER
OXIPZMKSNMRTIV-RNSTXJOVSA-N
RP-CAMPS TRIETHYL AMMONIUM SALT
CAMPS-RP, TRIETHYLAMMONIUM SALT
rp-camps triethylammonium salt hydrate
Rp-Cyclic AMPS (triethylammonium salt)
ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-RP, TRIETHYLAMMONIUM SALT
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt
Rp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine triethylammonium salt
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100530 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT Rp-cAMPS triethylammonium salt | 151837-09-1 | 1mg | 6750元 |
常見問題列表
生物活性
Rp-cAMPS triethylammonium salt，一種 cAMP 的類似物，是一種 cAMP 誘導(dǎo)的 PKA I 和 PKA II 活化 (Ki 分別為 12.5 μM 和 4.5 μM) 的有效的，競爭性拮抗劑。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。靶點(diǎn)
Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)
體外研究
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
體內(nèi)研究
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.