72873-74-6
中文名稱
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑
英文名稱
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
CAS
72873-74-6
分子式
C16H12FN3S
分子量
297.35
MOL 文件
72873-74-6.mol
更新日期
2023/10/26 17:11:16
72873-74-6 結(jié)構(gòu)式
基本信息
中文別名
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 英文別名
CS-1711SKF-86002
SKF 86002
SKF86002
SKF 86002 DIHYDROCHLORIDE
SKF-86002 - CAS 72873-74-6 - Calbiochem
6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thi
5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE
6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)189-190 °C(lit.)
沸點(diǎn)476.1±55.0 °C(Predicted)
密度1.39±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO: 9 mg/mL, soluble
酸度系數(shù)(pKa)4.36±0.10(Predicted)
形態(tài)solid
顏色off-white
InChIKeyYOELZIQOLWZLQC-UHFFFAOYSA-N
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331-H315-H319-H227
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說明26-36
WGK Germany3
海關(guān)編碼2934999090
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-12511 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 | 72873-74-6 | 2mg | 400元 |
| 2024/11/08 | HY-12511 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 | 72873-74-6 | 5 mg | 810元 |
| 2024/11/08 | HY-12511 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氫咪唑并[2,1-B]-噻唑 SKF-86002 | 72873-74-6 | 10mM * 1mLin DMSO | 891元 |
常見問題列表
生物活性
SKF-86002 是一種具有口服活性的 p38 MAPK 抑制劑，具有抗炎、抗關(guān)節(jié)炎和鎮(zhèn)痛活性。SKF-86002 能抑制脂氧合酶和環(huán)氧合酶介導(dǎo)的花生四烯酸代謝。體外研究
SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV).
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells.
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels.
Western Blot Analysis
| Cell Line: | U937 cells |
| Concentration: | 10 μM |
| Incubation Time: | 72 hours |
| Result: | Significantly reduced CD23 levels on IL-4-treated U937 cells. |
體內(nèi)研究
SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity.
| Animal Model: | Lewis rats, with adjuvant-induced arthritis (AA) |
| Dosage: | 10 mg/kg, 30 mg/kg, 90 mg/kg |
| Administration: | Oral administration, daily, for 22 days |
| Result: | Significantly decreased hindleg volumes after injection of adjuvant. |