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704869-38-5

中文名稱(chēng) N/A
英文名稱(chēng) SUN11602
CAS 704869-38-5
分子式 C26H37N5O2
分子量 451.604
MOL 文件 704869-38-5.mol
更新日期 2024/12/16 09:53:14
704869-38-5 結(jié)構(gòu)式 704869-38-5 結(jié)構(gòu)式

基本信息

中文別名
化合物SUN 11602
英文別名
CS-2504
SUN11602
SUN11602
SUN11602
4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
所屬類(lèi)別
生物化工:激動(dòng)劑抑制劑

物理化學(xué)性質(zhì)

沸點(diǎn)679.8±55.0 °C(Predicted)
密度1.19±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于DMSO
酸度系數(shù)(pKa)16.19±0.50(Predicted)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow
化合物SUN 11602價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-101493SUN11602704869-38-55mg700元
2024/11/08HY-101493SUN11602704869-38-510mM * 1mLin DMSO770元
2024/11/08HY-101493SUN11602704869-38-510mg1200元

常見(jiàn)問(wèn)題列表

生物活性
SUN11602是一種新型的堿性苯胺化合物,具有成纖維細(xì)胞生長(zhǎng)因子活性。
體外研究

SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons. SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons.

體內(nèi)研究

In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca 2+ . This Ca 2+ -capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis.

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