69542-93-4
中文名稱
匹伐加賓
英文名稱
Pivagabine
CAS
69542-93-4
分子式
C9H17NO3
分子量
187.24
MOL 文件
69542-93-4.mol
更新日期
2023/03/20 15:41:23
69542-93-4 結(jié)構(gòu)式
基本信息
中文別名
匹伐加賓4-新戊酰氨基丁酸
英文別名
TonergCXB 722
Pivagabine
PG 2 (pharmaceutical)
4-PivalaMidobutanoic acid
4-(Pivaloylamino)butanoic acid
N-trimethylacetyl-4-aminobutyric acid
4-(2,2-Dimethylpropionamido)butanoic acid
4-[(2,2-dimethylpropionyl)amino]butyric acid
Butanoic acid,4-[(2,2-diMethyl-1-oxopropyl)aMino]-
物理化學(xué)性質(zhì)
沸點(diǎn)397.0±25.0 °C(Predicted)
密度1.053±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.66±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Pivagabine (CXB 722) 是具有神經(jīng)調(diào)節(jié)活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血腦屏障。Pivagabine 拮抗足部休克對(duì)大鼠腦內(nèi) GABAA 受體功能和促腎上腺皮質(zhì)激素釋放因子 (CRF) 濃度的影響。體內(nèi)研究
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
| Animal Model: | Adult male Sprague-Dawley CD rats (200-250 g) |
| Dosage: | 200 mg/kg |
| Administration: | i.p.; twice a day for 4 days and 1 hour before killing on the 5th day |
| Result: | Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex. |