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646530-37-2

中文名稱 化合物UTL-5G
英文名稱 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
CAS 646530-37-2
分子式 C11H8Cl2N2O2
分子量 271.1
MOL 文件 646530-37-2.mol
更新日期 2024/12/16 10:38:27
646530-37-2 結(jié)構(gòu)式 646530-37-2 結(jié)構(gòu)式

基本信息

中文別名
化合物UTL-5G
英文別名
GBL-5g
UGL-5g
UTL-5g
3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-

物理化學(xué)性質(zhì)

沸點(diǎn)336.2±42.0 °C(Predicted)
密度1.469±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)9.45±0.70(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335

常見問題列表

生物活性
UTL-5g (GBL-5g) 是一種抗炎性 TNF-α 抑制劑,具有化學(xué)保護(hù)和肝臟放射保護(hù)作用。UTL-5g 通過抑制 TNF-α 等因子降低順鉑引起的肝毒性、腎毒性和骨髓毒性。
體外研究

RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 μM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.

體內(nèi)研究

UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.

Animal Model: C57BL/6, male mice (8-10 weeks)
Dosage: 15, 30, and 60 mg/kg
Administration: I.p.; before irradiation, daily x 5
Result: Blood levels of TGF-β were lowered.
Animal Model: BDF1 female mice
Dosage: P.o.; daily for 4 days
Administration: 60 mg/kg (30 min before i.p. injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0)
Result: Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.
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