6452-73-9
中文名稱(chēng)
鹽酸氧烯洛爾
英文名稱(chēng)
OXPRENOLOL HYDROCHLORIDE
CAS
6452-73-9
EINECS 編號(hào)
229-260-5
分子式
C15H24ClNO3
MDL 編號(hào)
MFCD00058008
分子量
301.81
MOL 文件
6452-73-9.mol
更新日期
2024/12/11 13:13:18
6452-73-9 結(jié)構(gòu)式
基本信息
中文別名
鹽酸氧烯洛爾 英文別名
1-[2-(ALLYLOXY)PHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL HYDROCHLORIDELABOTEST-BB LT00772178
OXPRENOLOL HYDROCHLORIDE
1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanohydrochloride
1-(o-allyloxyphenoxy)-3-isopropylaminopropan-2-olhydrochloride
2-(o-allyloxyphenoxy)-2-hydroxy-n-isopropyl-1-propylaminehydrochloride
ba-39089
c-39089-ba
ciba39089ba
1-[2-ALLYLOXYPHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOLHCl
2-Propanol, 1-(1-methylethyl)amino-3-2-(2-propenyloxy)phenoxy-, hydrochloride
(+-)-1-[o-(Allyloxy)phenoxy]-3-isopropylamino-2-propanol hydrochloride
1-(2'-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
1-(2-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride
1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propranol-hydrochloride
1-Isopropyl-amino-2-hydroxy-3-(O-allyloxyphenoxy)propane hydrochloride
1-Isopropylamino-3-(o-allyloxyphenoxy)-2-propanol hydrochloride
2-Propanol, 1-[(1-methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-, hydrochloride (9CI)
2-Propanol, 1-[o-(allyloxy)phenoxy]-3-(isopropylamino)-, hydrochloride (7CI, 8CI)
所屬類(lèi)別
原料藥：抗心律失常藥物理化學(xué)性質(zhì)
熔點(diǎn)91-93°C
儲(chǔ)存條件Store at +4°C
溶解度極易溶于水，易溶于酒精。
形態(tài)neat
顏色White to off-white
CAS 數(shù)據(jù)庫(kù)6452-73-9(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
防范說(shuō)明P264-P270-P301+P310+P330-P405-P501
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1 / PGIII
RTECS號(hào)UA5277000
Hazard NoteIrritant
危險(xiǎn)等級(jí)IRRITANT
海關(guān)編碼2922190900
毒性LD50 oral in rat: 214mg/kg
6452-73-9(安全特性,毒性,儲(chǔ)運(yùn))
儲(chǔ)運(yùn)特性
庫(kù)房通風(fēng)低溫干燥; 與食品原料分開(kāi)存放毒性分級(jí)
中毒急性毒性
口服-大鼠LD50: 900 毫克/公斤可燃性危險(xiǎn)特性
可燃;燃燒產(chǎn)生有毒氮氧化物和氯化氫煙霧類(lèi)別
有毒物品滅火劑
干粉、泡沫、砂土、二氧化碳, 霧狀水常見(jiàn)問(wèn)題列表
生物活性
Oxprenolol hydrochloride (Ba 39089) 是一種口服有效的 β-腎上腺素受體 (β-AR) 拮抗劑，Ki 為 7.10 nM。靶點(diǎn)
Ki: 7.10 nM (β-adrenergic receptor)
體內(nèi)研究
Oxprenolol (200 mg/kg/day; administered orally; for 3 weeks) produces effective beta-blockade.
| Animal Model: | Male rats (230 to 300 g body wt) of the Wistar strain |
| Dosage: | 200 mg/kg |
| Administration: | Administered orally; daily for 3 weeks |
| Result: | This dosage produced effective beta-blockade. |