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6192-62-7

中文名稱 番茄堿
英文名稱 TOMATIDINE HYDROCHLORIDE
CAS 6192-62-7
分子式 C27H46ClNO2
分子量 452.11
MOL 文件 6192-62-7.mol
更新日期 2024/12/17 08:53:50
6192-62-7 結構式 6192-62-7 結構式

基本信息

中文別名
番茄堿鹽酸鹽
英文別名
TOMATIDINE HCL
TOMATIDINE HCL(RG)
TOMATIDINE HYDROCHLORIDE
ToMatidin Hydrochloride, >85%
Tomatidine, Hydrochloride, >85%
5α-Tomatidan-3β-ol hydrochloride
SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
3β-Hydroxy-5α-tomatidane hydrochloride
5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
(3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
所屬類別
生物化工:植物提取物

物理化學性質(zhì)

熔點281-284°C (dec.)
儲存條件2-8°C
溶解度少許溶于甲醇
形態(tài)類白色固體
顏色白色至灰白色
BRN3920740

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
安全說明22-24/25
WGK Germany3

應用領域

用途1
用于含量測定/鑒定/藥理實驗等。

圖譜信息

番茄堿價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-N2149A番茄堿
Tomatidine hydrochloride
6192-62-75mg500元
2024/11/08HY-N2149A番茄堿
Tomatidine hydrochloride
6192-62-710mg700元
2024/11/08HY-N2149A番茄堿
Tomatidine hydrochloride
6192-62-725 mg1400元

常見問題列表

生物活性
Tomatidine hydrochloride 通過阻斷 NF-κB 和 JNK 信號發(fā)揮抗炎作用。Tomatidine hydrochloride 激活哺乳動物細胞或秀麗隱桿線蟲中的自噬 (autophagy)。
靶點

p65

JNK

體外研究

Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.

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