6192-62-7
基本信息
TOMATIDINE HCL(RG)
TOMATIDINE HYDROCHLORIDE
ToMatidin Hydrochloride, >85%
Tomatidine, Hydrochloride, >85%
5α-Tomatidan-3β-ol hydrochloride
SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL
3β-Hydroxy-5α-tomatidane hydrochloride
5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE
(3β,5α,22β,25S)-Spirosolan-3-ol Hydrochloride
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-N2149A | 番茄堿 Tomatidine hydrochloride | 6192-62-7 | 5mg | 500元 |
2024/11/08 | HY-N2149A | 番茄堿 Tomatidine hydrochloride | 6192-62-7 | 10mg | 700元 |
2024/11/08 | HY-N2149A | 番茄堿 Tomatidine hydrochloride | 6192-62-7 | 25 mg | 1400元 |
常見問題列表
p65
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JNK
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Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.