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6153-64-6

中文名稱 地霉素
英文名稱 Oxytetracycline dihydrate
CAS 6153-64-6
EINECS 編號 209-271-1
分子式 C22H28N2O11
MDL 編號 MFCD00151234
分子量 496.46
MOL 文件 6153-64-6.mol
更新日期 2023/03/20 15:41:19
6153-64-6 結(jié)構(gòu)式 6153-64-6 結(jié)構(gòu)式

基本信息

中文別名
4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氫-3,5,6,10,12,12a-六羥基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺
4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氫-3,5,6,10,12,12a-六羥基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺二水合物
6-甲基-4-(二甲氨基)-3,5,10,12,12a-五羥基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氫-2-并四苯甲酰胺
地霉素
多西環(huán)素
強力霉素
土霉素
土霉素注射液
脫氧土霉素
氧四環(huán)素
氧四環(huán)素/土霉素 二水合物
二水合土霉素
地霉素
強力霉素
土霉素二水合物
英文別名
4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate
5-hydroxytetracycline
OXYTETRACYCLINE DIHYDRATE
terramycin
OXYCYCLINE
DOXYCYCLINE USP 23
OXYTETRACYCLINE HCL BP
DOXYCYCLINE HYDRATE BP98 USP23
DOXYCYCLINE HYCHLATE
DOXYCYCLINE HCL ( VETERINARY)
trramycin
OXYTETRACYCLINE DIHYDRATE SIGMAULTRA
OxytetracyclineHcl2058-46-0,
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, dihydrate, (4S,4aR,5S,5aR,6S,12aS)-
OXYTETRACYCLINEFEED
OXYTETRACYCLINE DIHYDRATE, INJECTABLE GRADE
OXYTETRACYCLINE DIHYDRATE, ORAL GRADE
4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate

物理化學(xué)性質(zhì)

熔點181-182 °C
比旋光度-216 º (c=1,0.1 M HCl)
儲存條件0-6°C
溶解度1 M HCl: 0.1 M yellow to yellow-orange, clear
形態(tài)crystalline
形態(tài)crystalline
顏色yellow
顏色黃色
水溶解性微溶
CAS 數(shù)據(jù)庫6153-64-6(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Oxytetracycline dihydrate (6153-64-6)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09
警示詞警告
危險性描述H361d-H411
危險品標(biāo)志Xn
危險類別碼R63-R36
WGK Germany3
海關(guān)編碼29413020

應(yīng)用領(lǐng)域

用途一
阻止aminoacyl-tRNA結(jié)合到30S亞單元上,抑制蛋白質(zhì)合成(延長期)??咕V: 革蘭氏陰性和陽性菌

知名試劑公司產(chǎn)品信息

常見問題列表

生物活性
Oxytetracycline Dihydrate 是一種處方抗生素,干擾細菌產(chǎn)生必需蛋白質(zhì)的能力。
靶點

HSV-1

Bacterial

Human Endogenous Metabolite

體外研究

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

體內(nèi)研究

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis , the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

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