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611-59-6

中文名稱 1,7-二甲基黃嘌呤
英文名稱 1,7-DIMETHYLXANTHINE
CAS 611-59-6
分子式 C7H8N4O2
分子量 180.16
MOL 文件 611-59-6.mol
更新日期 2024/12/24 08:55:10
611-59-6 結(jié)構(gòu)式 611-59-6 結(jié)構(gòu)式

基本信息

中文別名
咖啡因雜質(zhì)F
1,7-二甲基黃嘌呤
1,7-二甲基黃嘌呤 ~98%
1, 7-二甲基黃嘌呤溶液, 100PPM
英文別名
PARAXANTHINE
Paraxanthine-d3
Caffeine IMpurity F
1,7-DIMETHYLXANTHINE
Paraxanthine solution
1,7-dimethyl-3H-purine-2,6-dione
1,7-dimethyl-1h-purine-2,6-dione
2,6-DIHYDROXY-1,7-DIMETHYLPURINE
1,7-diMethyl-1H-purine-2,6(3H,7H)-dione
3,7-dihydro-1,7-dimethyl-1h-purine-6-dione
所屬類別
分析化學(xué):標準物質(zhì)

物理化學(xué)性質(zhì)

熔點294-296 °C(lit.)
沸點312.97°C (rough estimate)
密度1.3640 (rough estimate)
折射率1.6700 (estimate)
閃點9℃
儲存條件-20°C冷凍
溶解度ethanol: 0.6mg/mL
酸度系數(shù)(pKa)pKa 8.5 (Uncertain)
形態(tài)solid
顏色white
BRN197907
穩(wěn)定性在室溫下密封存放
InChIInChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)
InChIKeyQUNWUDVFRNGTCO-UHFFFAOYSA-N
SMILESN1(C)C2=C(NC(=O)N(C)C2=O)N=C1

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
防范說明P301+P312+P330
危險品標志Xn,T,F
危險品運輸編號UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS號RV9380000
海關(guān)編碼2933.59.9500
毒性mmo-esc 150 mg/L CSHSAZ 16,337,52
1,7-二甲基黃嘌呤價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-W0164981,7-二甲基黃嘌呤
Paraxanthine
611-59-625mg700元
2024/11/08HY-W0164981,7-二甲基黃嘌呤
Paraxanthine
611-59-610mM * 1mLin DMSO770元
2024/11/08HY-W0164981,7-二甲基黃嘌呤
Paraxanthine
611-59-650mg1000元

常見問題列表

生物活性
Paraxanthine,caffeine的代謝物,可通過刺激Ryanodine受體通道來抑制多巴胺能細胞的死亡。
靶點

Ryanodine Receptor Channels

Human Endogenous Metabolite

體外研究

When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH +neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH +neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH + cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase).

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