58337-38-5
中文名稱
EHNA
英文名稱
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
CAS
58337-38-5
分子式
C14H24ClN5O
分子量
313.826
MOL 文件
58337-38-5.mol
58337-38-5 結構式
基本信息
中文別名
外消旋-9-(2-羥基-3-壬基)腺嘌呤鹽酸鹽 英文別名
rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salterythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
常見問題列表
生物活性
EHNA hydrochloride 是一個強有力的和選擇性的環(huán)核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脫氨酶 (ADA) 的雙重抑制劑。EHNA hydrochloride 濃度依耐性抑制 cGMP 刺激的 PDE2 的活性，IC50 值分別為 0.8 μM (人類) 和 2 μM (豬心肌)，但是對沒有刺激的 PDE2 抑制力較小。EHNA hydrochloride 在調節(jié)多種藥理反應中發(fā)揮作用，包括抗病毒、抗腫瘤和抗心律失常作用。靶點
|
hPDE2A 0.8 μM (IC 50 ) |
體外研究
EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.