| Identification | Back Directory | [Name]
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride | [CAS]
58337-38-5 | [Synonyms]
rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt
erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride | [Molecular Formula]
C14H24ClN5O | [MDL Number]
MFCD00151066 | [MOL File]
58337-38-5.mol | [Molecular Weight]
313.826 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). | [Definition]
ChEBI: (2R,3S)-EHNA hydrochloride is a hydrochloride salt obtained by reaction of (2R,3S)-EHNA with one equivalent of hydrochloric acid. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and an EC 3.5.4.4 (adenosine deaminase) inhibitor. It contains a (2R,3S)-EHNA(1+). | [General Description]
EHNA is an adenosine deaminase inhibitor. It possesses antitumor action. | [storage]
Room temperature |
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Sigma-Aldrich
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